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TOXICOLOGICAL INFORMATION(continued) <br />sensitizer in animals. <br />In lifetime inhalation studies of respirable titanium dioxide at <br />levels up to 250 mg/m3, no compound related clinical signs of <br />toxicity were seen in the exposed animals. Slight <br />pulmon <br />fibrosis was seen at 50 to 250 mg/m3 respirable tittaniuumadioxide <br />but not at 10 mg/m3. There was no evidence of cancer in animals <br />exposed to 10 or 50 mg/m3 respirable titanium dioxide. <br />Microscopic lung tumors were seen in 17 percent of the rats <br />exposed to 250 mg/m3 respirable titanium dioxide. The lung tumors <br />observed in the rats were different from common human lung <br />cancers, relative to anatomic type and location, and occurred only <br />at dust levels which overwhelmed the animals lung clearance <br />mechanism and therefore, are of questionable biological relevance <br />for man. In lifetime animal feeding tests at levels up to 50,000 <br />ppm, titanium dioxide showed iio evidence of cancer or other <br />significant adverse effects in either rats or mice. <br />ECOLOGICAL INFORMATION <br />Ecotoxicological Information <br />Aquatic Toxicity <br />96 -hour LC50, fathead minnows: >1,000 mg/L <br />DISPOSAL CONSIDERATIONS <br />Waste Disposal <br />Comply with Federal, State, and local regulations. If <br />approved, remove to land disposal area. <br />TRANSPORTATION INFORMATION <br />Shipping Information <br />Shipping Containers <br />Tank Cars. <br />Tank Trucks. <br />NOT REGULATED AS A HAZARDOUS MATERIAL BY DOT OR IMO. <br />REGULATORY INFORMATION <br />U.S. Federal Regulations <br />TSCA Inventory Status Reported/Included. <br />TITLE III HAZARD CLASSIFICATIONS SECTIONS 311, 312 <br />Acute : No <br />(Continued) <br />6200CR o <br />