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Toxicicity (SEE DATA BELOW) Acute oral toxicity - LD50 < 2500 mg/kg Acute dermal toxicity - LD50 < 4300 mg/kg = Inhalation - LC50 < 10,000 ppm Acute aquatic toxicity 96 -hour LC50 < 500 mg/I SODIUM SULFATE Animal Toxicity Studies: Non -Human Toxicity Excerpts: SEP 19 2014 ENVIRONKENTAL HEALTH DEPARTMENT GUINEA PIGS WERE EXPOSED FOR PERIOD OF 1 HR TO AEROSOLS OF SULFATE SALTS. WITH EXCEPTION OF SODIUM SULFATE, ALL SULFATES CAUSED SLIGHT INCR IN PULMONARY FLOW RESISTANCE & SLIGHT DECR IN PULMONARY COMPLIANCE. [AMDUR MO ET AL; COMPARATIVE IRRITANT POTENCY OF SULFATE SALTS; ENVIRON RES 16 (1-3): 1-8 (1978)] **PEER REVIEWED** Outbreaks of poisoning in pigs due to overdosage ... /were characterized by/ nervous signs, twitching, tremors & convulsions. The most noticeable lesion at post mortem was widespread vacuolation & necrosis of cerebral cortex.... The sodium concn of cerebrospinal fluid ... was usually (but not always) significantly higher than normal. The condition was reproduced experimentally by drenching 8 wk old pigs with 50 g anhydrous sodium sulfate daily for 3 days & restricting their water supply. [Clarke, M. L., D. G. Harvey and D. J. Humphreys. Veterinary Toxicology. 2nd ed. London: Bailliere Tindall, 1981., p. 42] **QC REVIEWED** Gambusia affinis mortality incr with incr of exposure time to Kraft pulp mill waste constituents. Sodium sulfate was the least toxic constituents to the fish. [Prased DY; Toxicity of Kraft Pulp Mill Waste Constituents on Fresh Water Gambusia affinis; Indian Pulp Pap 35 (2): 9-12 (1980)] **QC REVIEWED** Sulfate levels of 7000 mg/I resulted in weight loss in cattle; rats were not harmed by 15,000 mg/I. /Sulfate/ [Environment Canada; Tech Info for Problem Spills: Sodium Sulphate p.41 (1985)] **QC REVIEWED** Poultry mortality was 33% after drinking water containing 7500 mg/I sodium sulfate for 15 days. [Environment Canada; Tech Info for Problem Spills: Sodium Sulphate p.41 (1985)] **QC REVIEWED**