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intravenous-rat LD50Sw660 mg/kg MELAAD 54, 486;63
<br /> inhalation-mouse LC50:5320 ppm/8H JIHTAB 25, 366, 43
<br /> intraperitoneal-mouse LD50:640 mg/kg ANYAA9 243, 104, 75
<br /> inhalation-rabbit, adult LCLo:55, 000 ppm/40M JIDHAN 26, 69, 44
<br /> skin-rabbit, adult LD50: 12, 124 mg/kg AIHAAP 30, 470, 69
<br /> Consensus Reports:
<br /> Community Right-To-Know List. Reported in EPA TSCA Inventory. EPA
<br /> Genetic Toxicology Program.
<br /> Standards and Recommendations:
<br /> OSHA PEL: TWA 100 ppm; STEL 150 ppm
<br /> ACGIH TLV: TWA 50 ppm (skin) ; BEI: 1 mg (toluene) /L in venous blood at
<br /> end of shift; 20 ppm toluene in end-exhaled air during shift
<br /> DFG MAK:100 ppm (380 mg/m3) ; BAT: 340 mg/dL in blood at end of shift.
<br /> NIOSH REL: (Toluene) TWA 100 ppm; CL 200 ppm/10M
<br /> DOT Classification: 3; Label: Flammable Liquid
<br /> SAFETY PROFILE:
<br /> Poison by intraperitoneal route. Moderately toxic by intravenous and
<br /> subcutaneous routes. Mildly toxic by inhalation. An experimental
<br /> teratogen. Human systemic effects by inhalation: CNS recording changes,
<br /> hallucinations or distorted perceptions, motor activity changes,
<br /> antipsychotic, psychophysiological test changes, and bone marrow
<br /> changes. Experimental reproductive effects. Mutation data reported. A
<br /> human eye irritant. An experimental skin and severe eye irritant.
<br /> Toluene is derived from coal tar, and commercial grades usually contain
<br /> small amounts of benzene as an impurity. Inhalation of 200 ppm of
<br /> toluene for 8 hours may cause impairment of coordination and reaction
<br /> time; with higher concentrations (up to 800 ppm) these effects are
<br /> increased and are observed in a shorter time. In the few cases of acute
<br /> toluene poisoning reported, the effect has been that of a narcotic, the
<br /> workman passing through a stage of intoxication into one of coma.
<br /> Recovery following removal from exposure has been the rule. An
<br /> occasional report of chronic poisoning describes an anemia and
<br /> leukopenia, with biopsy showing a bone marrow hypoplasia. These effects,
<br /> however, are less common in people working with toluene, and they are
<br /> not as severe. At 200-500 ppm, headache, nausea, eye irritation, loss of
<br /> appetite, a bad taste, lassitude, impairment of coordination and
<br /> reaction time are reported, but are not usually accompanied by any
<br /> laboratory or physical findings of significance. With higher
<br /> concentrations, the above complaints are increased and in addition,
<br /> anemia, leukopenia, and enlarged liver may be found in rare cases. A
<br /> common air contaminant, emitted from modern building materials (CENEAR
<br /> 69,22, 91) . Used in production of drugs of abuse.
<br /> Flammable liquid. A very dangerous fire hazard when exposed to heat,
<br /> flame, or oxidizers. Explosive in the form of vapor when exposed to heat
<br /> or flame. Explosive reaction with 1, 3-dichloro-5, 5-dimethyl-2, 4-
<br /> imidazolididione; dinitrogen tetraoxide; concentrated nitric acid; H2SO4
<br /> + HNO3; N204; AgC104; BrF3, UF6, sulfur dichloride. Forms an explosive
<br /> mixture with tetranitromethane. Can react vigorously with oxidizing
<br /> 12
<br /> Site Safety S Health Plan Rev./1. 0
<br /> October 20, 1997
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