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skin-rabbit, adult 50N ng/24H MOD 28ZPAK -,24, 72—
<br /> eyes-rabbit, adult 87 mg MLD AMIHAB 14, 387, 56
<br /> eyes-rabbit, adult 5 mg/24H SEV 28ZPAK -, 24, 72
<br /> cyt-smc 1 mmol/tube HEREAY 33, 457, 47
<br /> inhalation-rat TCLo:50 mg/m3/6H (female 1-21D post) : Reproductive
<br /> effects JOHYAY 27, 337, 83
<br /> inhalation-mouse TCLo: 4000 ppm/6H (female 6-12D post) : Reproductive
<br /> effects TJADAB 28, 22A, 83
<br /> inhalation-rat TCLo:50 mg/m3/6H (female 1-21D post) : Teratogenic effects
<br /> JOHYAY 27, 337, 83
<br /> inhalation-rabbit, adult TCLo: l g/m3/24H (female 7-20D post) :
<br /> Reproductive effects ARTODN 8, 425, 85
<br /> inhalation-rat TCLo:50 mg/m3/6H (female 1-21D post) : Reproductive
<br /> effects JOHYAY 27, 337, 83
<br /> oral-mouse TDLo: 31 mg/kg (female 6-15D post) : Reproductive effects
<br /> JTEHD6 9, 97, 82
<br /> inhalation-rat TCLo:50 mg/m3/6H (female 1-21D post) : Teratogenic effects
<br /> JOHYAY 27, 337, 83
<br /> inhalation-rat TCLo:250 mg/m3/24H (female 7-15D post) : Teratogenic
<br /> effects ARTODN 8, 425, 85
<br /> inhalation-rat TCLo:50 mg/m3/6H (female 1-21D post) : Teratogenic effects
<br /> JOHYAY 27, 337, 83
<br /> oral-human LDLo:50 mg/kg YAKUD5 22, 883, 80
<br /> inhalation-man LCLo:10000 ppm/6H BMJOAE 3, 442, 70
<br /> inhalation-human TCLo:200 ppm:NOSE,EYE,PUL JIHTAB 25, 282, 43
<br /> oral-rat LD50 :4300 mg/kg AMIHAB 14, 387,56
<br /> inhalation-rat LC50:5000 ppm/4H NPIRI* 1, 123, 74
<br /> intraperitoneal-rat LD50 :2459 mg/kg ENVRAL 40, 411, 86
<br /> Consensus Reports:
<br /> Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
<br /> Community Right-To-Know List.
<br /> Standards and Recommendations:
<br /> OSHA PEL: TWA 100 ppm; STEL 150 ppm
<br /> ACGIH TLV: TWA 100 ppm; STEL 150 ppm; BEI: 1.5 g (methyl hippuric
<br /> acids) /g creatinine in urine end of shift.
<br /> DFG MAK: (all isomers) 100 ppm (440 mg/m3) ; BAT: 150 mg/dL in blood at
<br /> end of shift.
<br /> NIOSH REL: (Xylene) TWA 100 ppm; CL 200 ppm/lOM
<br /> DOT Classification: 3; Label: Flammable Liquid
<br /> SAFETY PROFILE:
<br /> Moderately toxic by intraperitoneal and subcutaneous routes. Mildly
<br /> toxic by ingestion and inhalation. An experimental teratogen. Human
<br /> systemic effects by inhalation: olfactory changes, conjunctiva
<br /> irritation, and pulmonary changes. Experimental reproductive effects.
<br /> Mutation data reported. A human eye irritant. An experimental skin and
<br /> severe eye irritant. Some temporary corneal effects are noted, as well
<br /> as some conjunctival irritation by instillation (adding drops to the
<br /> eyes one drop at a time) . Irritation can start @ 200 ppm. A very
<br /> dangerous fire hazard when exposed to heat or flame; can react with
<br /> oxidizing materials. To fight fire, use foam, CO2, dry chemical. When
<br /> heated to decomposition it emits acrid smoke and irritating fumes. See
<br /> also other xylene entries.
<br /> 15
<br /> Site Safety 6 Health Plan Rev./1.0
<br /> October 20, 1997
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