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o Instrument Calibration <br /> a GUMS 5ystens <br /> The pas chromatographic/crass spectrometry systens are calibrated <br /> for nass and then tuned using specific instrument and method <br /> parameters . They are then calibrated for quantitation using <br /> either the external or the internal standard techniques . <br /> Specific methods nay impose variations and/or different <br /> acceptance criteria upon both the tuning and calibration <br /> techniques . These specific requirements are found in the <br /> CHEmUCST SOP cowering the particular method in question . <br /> o Mass Calibration and Tunings <br /> Calibrating and tuning the GCMS systems is both instrument <br /> and method specific, and includes, but is not limited to, <br /> the following general actions <br /> o Introduction of the proper mass calibration compound <br /> into the GCMS system Cie fC73 <br /> Eperfluorotributylamine3): <br /> a Running the proper GCHS calibration procedure Cie CR <br /> on the Finnigan 5100'5)t <br /> o Documenting the calibration: <br /> o Introduction of the proper tuning compound into the <br /> GChS system Cie orB Cbronafluorobenzene3 for <br /> volatiles: DFTPP Cdecafluorotriphenylanine3 for <br /> semi-volatiles); <br /> o Running the proper GCMS tuning program Cie . MTUHE on <br /> the Finnigan 5100) <br /> r <br /> o Making the correct instrument adjustments to meet the <br /> nethod specific tuning criteria: <br /> o Documenting the tune . <br /> o External Standard Calibration Procedures <br /> for each analyte, or group of analytes, flue concentration <br /> levels of standards are prepared by adding aliquots of one <br /> or more stock standards to volumetric flasks and diluting <br /> to volume with an appropriate solvent . One of the <br /> 1 standards should be at a concentration near the method <br /> detection limit. The other concentrations should define <br /> the working range of the system. <br /> 15 <br /> t <br />