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' DIESEL 20 ' operations. E. HEALTH AND HAZARD INFORMATION ' VARIABILITY AMONG INDIVIDUALS Health studies have shown that many petroleum hydrocarbons and synthetic lubricants pose ' potential human health risks which may vary from person to person. As a precaution, exposure to liquids, vapors, mists or fumes should be minimized. EFFECTS OF OVEREXPOSURE (Signs and symptoms of exposure) Prolonged or repeated liquid contact with the skin will dry and defat the skin, leading to ' possible irritation and dermatitis. High vapor concentrations (greater than approximately 1000 ppm, attainable at temperatures well above ambient) are irritating to the eyes and the respiratory tract, and may cause headaches, dizziness, anesthesia, drowsiness, unconsciousness, and other central nervous ' system effects, including death. NATURE OF HAZARD AND TOXICITY INFORMATION Prolonged or repeated skin contact with this product tends to remove skin oils, possibly ' leading to irritation and dermatitis: however, based on human experience and available toxicological data, this product is judged to be neither a 'corrosive' nor an 'irritant' by OSHA criteria. ' Product contacting the eyes may cause eye irritation. Lifetime skin painting studies conducted by the American Petroleum Institute, Exxon and others have shown that similar products boiling between 175-370'C (350-700' F) usually produce skin tumors and/or skin cancer in laboratory mice. The degree of carcinogenic response was ' weak to moderate with a relatively long latent period. The implications of these results for humans have not been determined. Limited studies on oils that are very active carcinogens have shown that washing the animals' ' skin with soap and water between applications greatly reduces tumor formation. These studies demonstrate the effectiveness of cleansing the skin after contact. Potential risks to humans can be minimized by observing good work practices and personal hygiene procedures generally recommended for petroleum products. See Section I for recommended ' protection and precautions. Contains light hydrocarbon components. Lifetime studies by the American Petroleum Institute have shown that kidney damage and kidney cancer can occur ' to male rats after prolonged inhalation exposures at elevated concentrations of total gasoline. Kidneys of mice and female rats were unaffected. The U.S. EPA Risk Assessment Forum has concluded that the male rat kidney tumor results are not relevant for humans. Total gasoline exposure also produced liver tumors to female mice only. The implication of these data for humans has not ' been determined. Certain components, such as normal hexane, may also affect the nervous system at high concentrations (e.g. . 1000-1500 ppm). Product has a low order of acute oral and dermal toxicity, but minute amounts aspirated into ' the lungs during ingestion or vomiting may cause mild to severe pulmonary injury and possibly death. This product is judged to have an acute oral LD50 (rat) greater than 5 g/kg of body weight, and an acute dermal LD50 (rabbit) greater than 3. 16 9/kg of body weight. ' Inhalation of components of exhaust from burning, such as carbon monoxide, may cause death at high concentrations. Long-term repeated exposure of laboratory animals to whole diesel exhaust has resulted in an ' Increased Incidence of lung cancer. Exposure to exhaust from burning and diesel exhaust should be minimized. PRE-EXISTING MEDICAL CONDITIONS WHICH MAY BE AGGRAVATED BY EXPOSURE Petroleum Solvents/Petroleum Hydrocarbons - Skin contact may aggravate an existing dermatitis. ' /11/92 s�soz niww',00 is DATE 355UED: 09 PAGE : 3 S" OORSEDES DATE: 12/02/91