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0E' 9raatest cancsrn. are. recant. finding3- concluding that: DCM is a <br /> clsar, animal carcinogen: (In March 29, 19831 the National ToKfcology <br /> Program, (NTP), Board' of Scientific. Counaelars Phar Review Panel approved _ - <br /> tha following conciuszana regarding theit4TP methyione chloride <br /> i-nhalation bioassays <br /> "Under- the conditions of the NTP tnhalatton <br /> bfcassay th&re, Was. some. nvidz-nce of <br /> �rrcins�kenic+ }v of dichlaromathane for mals F344/N <br /> rats as shown by an increased' incidenceof benign <br /> neoplasms: of the. mammary gland.. Thera wafa'. cle r <br /> evict ncr+ of c rci'nanenicity of dichloromethane for <br /> femaia F344/N rats as shown by the increased <br /> incrdence. of benign- neopiacma of the mammary <br /> gland: Thera- was: cl ear avi'dencz? of <br /> carr- rinatlntgjty of dichloromethane for male and <br /> female 26C,T.,ri mica as shown by increased - <br /> inci'dences: of alveolar/bronchiolar neoplasims. and <br /> heptdcallular neoplasms. "� - <br /> Theser -flndings: are, consistent with other DCM inhalation bioassays on. <br /> r.ats.'-- <br /> Where a, subatance is: found: to be a. sufficient evidence animal <br /> carcinogen and- thane- is an: abaence of adequate data in. humans,,, as is <br /> the Ca-,UL with mothyiane chloride*, a: presumption arises: that. the <br /> substance- po3es< a, carctnogpnic: rtzk-, to: humans:a Based' on the- NTP and. <br /> other- research: fi-ndino-,w and, the use of. reeounized. risk: extrapolation: <br /> modals,,l' ' the Commission staff estimates that the use- of a-, Paint. <br /> CPSC; SSF7',. Juna 1963; Tib A, at 3. <br /> 7 Id'. 9 <br /> e "Tn accordance.• withitha: policies. Of' the International' Agency <br /> for. Research on Cancer', the. Whito- House Office- of Sci-encm and <br /> Technology Policy.. the. Dupartment. of Health and Human Services <br /> and thQ: Fnvir.onmantal frotoctinn Agency, the, finding. of: <br /> sufficient avidenca: in. animals, and- the abssnce of adaquate. data <br /> in. humana; means, that- for, practical purposemT methylene chlor-i'de <br /> can be: regarded as. prasenting a carcinogenic risk to humans. " <br /> CPSC; SSPT June <br /> Tab C' at 2, - - <br /> so . Tab: C. - <br /> •V <br />