Laserfiche WebLink
SECTIONS ESN gncenalnUes and Unilladons <br /> 0 Extrapolation of data from (1) high dose animal studies to low-dose human exposures, (2) <br /> acute or subchronic exposure to chronic exposure, and (3) one exposure route to another <br /> (e g, from ingestion to inhalation or dermal absorption) <br />' 0 Use of single-chemical test data that do not account for multiple exposures or synergistic <br /> and antagonistic responses <br />' 7.5 RISK CHARACTERIZATION <br /> Because there are uncertainties in each step of the risk assessment process, these uncertainties are often <br /> magnified in the final risk characterization The final quantitative estimates of risk may be one or <br /> several orders of magrutude ditlerent from the potential risk associated with a given exposure In an <br /> attempt to minimize the consequences of uncertainty, EPA guidance typically relies on use of <br /> conservative estimates of hazards in the absence of strong scientific data. The overall result is that risk <br /> estimates presented in this report are much more likely to overestimate the potential risk rather than to <br /> underestimate it <br /> In this risk assessment RMEs were used to estimate risk Average risks are considered to be best <br /> estimates, whereas RME risk represents an upperbound estimate Because RME risk estimates are <br /> based on a combination of conservative assumptions, the RME estimates are highly unlikely to reflect <br /> nsks generally encountered at the site <br /> The assessment has been prepared in a manner consistent with that generally used in the consulting <br /> community and agency guidance at the time it was prepared It is likely that nsk assessment methods <br /> and data identifying and quantifying the toxicity of chemicals will improve with time <br /> Tk,Se7*73000NAWOCKYohnaEPoRT%SHOR wo 7-4 <br />