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SAX'S Dangerous Properties of Industrial Materials,Ninth Edition
<br /> JAMAAP 123,1106,43 (12)
<br /> Inhalation Man TCLo 100 ppm Central nervous system effects WEHRBJ 9,131,72 (13)
<br /> Oral-Rat LD50 5000 mg/kg AMIHAB 19,403,59 (14)
<br /> Inhalation-Rat LCLo 4000 ppm/4H AIHAAP 30,470,69(15)
<br /> Intraperitoneal-Rat LD50 1332 ing/kg ENVRAL 40 411,86(16)
<br /> Intravenous-Rat LD50 1960 mgl g MELAAD 54,486,63 (17)
<br /> Unreported-Rat LD50 6900 mg/kg GISAAA 45(12),64,80(I8)
<br /> Inhalation Mouse LC50 400 ppm124H NRTXDN 2,567,81 (19)
<br /> Intraperitoneal Mouse LD50 59 mg/kg AT TXDN 2,5 6 7.81 (2 0)
<br /> Subcutaneous Mouse LD50 2250 mg/kg NR TXDN 8,2 3 7,8 7(2 1)
<br /> Unreported Mouse LD50 2 g/kg GISAAA 45(12),64,80(22)
<br /> Intraperitoneal Mouse LD50 640 mg/kg ANYAA9 243,104,75(23)
<br /> Inhalation-Rabbit, adultLCLo 55,000ppm/40M JIDHA N 2 6,6 9,4 4(2 4)
<br /> Skin Rabbit adult LD50 12,124 mg/kg AIHAAP 30,470,69 (25)
<br /> Consensus Reports*
<br /> Community Right-To-Know List Reported in EPA TSCA Inventory EPA Genetic Toxicology
<br /> Program
<br /> Standards and Recommendations
<br /> OSHA PEL TWA 100 ppm, STEL 150 ppm
<br /> ACGIH TLV TWA 50 ppm (skin), BEI 1 mg(toluene)/L in venous blood at end of shift, 20
<br /> ppm toluene in end-exhaled air during shift
<br /> DFG MAK 50 ppm (190 mg/m3), BAT 340 pg/dL in blood at end of shift
<br /> NIOSH REL (Toluene) TWA 100 ppm, CL 200 ppm/10M
<br /> DOT Classification 3, Label Flammable Liquid
<br /> SAFETY PROFILE:
<br /> Poison by intraperitoneal route Moderately toxic by intravenous and subcutaneous routes Mildly
<br /> toxic by inhalation An experimental teratogen Human systemic effects by inhalation CNS
<br /> recording changes, hallucinations or distorted perceptions, motor activity changes, antipsychotic,
<br /> psychophysiological test changes, and bone marrow changes Experimental reproductive effects
<br /> Mutation data reported A human eye irritant An experimental skin and severe eye irritant
<br /> Toluene is derived from coal tar, and commercial grades usually contain small amounts of
<br /> benzene as an impurity Inhalation of 200 ppm of toluene for 8 hours may cause impairment of
<br /> coordination and reaction time, with higher concentrations (up to 800 ppm) these effects are
<br /> increased and are observed in a shorter time In the few cases of acute toluene poisoning reported,
<br /> the effect has been that of a narcotic, the workman passing through a stage of intoxication into
<br /> one of coma Recovery following removal from exposure has been the rule An occasional report
<br /> of chronic poisoning describes an anemia and leukopenia, with biopsy showing a bone marrow
<br /> hypoplasia These effects, however, are less common in people working with toluene, and they are
<br /> not as severe At 200-500 ppm, headache, nausea, eye irritation, loss of appetite, a bad taste,
<br /> lassitude, impairment of coordination and reaction time are reported, but are not usually
<br /> C 1996 Van Nostrand Reinhold Company,New York Pg 2 All Rights Reserved
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