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BENZENE 9705U9-00 aage c <br /> XI . TOXICOLOGICAL DATA <br /> ---ACUTE TOXICOLOGY— <br /> ORAL TOXICITY (RATS) : LD50 •. 3 . 800 g/kg Moderately toxic <br /> DEAL TOXICITY (RABBITS) : Slightly toxic <br /> INHALATION TOXICITY (RATS) : LC50 : 16000 PPM FOR 4 HRS . Toxic <br /> EYE IRRITATION (RABBITS) : Caused moderate irritation to rabbits. Eye <br /> irritation scores: 18 . 0 at 24 hours , 18 . 0 at 48 hours , 4. 0 at 72 <br /> hours, 0 at 7 days. <br /> SKIN IRRITATION (RABBITS) : Moderately irritating to rabbits . <br /> ---GENETIC TOXICOLOGY (SUMMARY) --- <br /> �7 Benzene was not mutagenic in most mutagenicity test systems, but has <br /> been reported to induce chromosomal changes in bone marrow and <br /> blood cells of some exposed workers. <br /> ---REPRODUCTIVE TOXICOLOGY (SUMMARY) --- <br /> Some animal studies suggest that severe overexposure to benzene may <br /> result in growth retardation to the developing fetus . Some effects <br /> on reproductive organs in mice have also been reported. <br /> ---CHRONIC TOXICOLOGY (SUMMARY) --- <br /> Animal studies with benzene by inhalation or by oral, administration have <br /> resulted in evidence of carcinogenic effects in a number of tissues <br /> and organs, adverse effects on the immune system, chromosomal <br /> !� changes, anemia and possibly leukemia . Both NTP and IARC list <br /> benzene as a human carcinogen. Long-term exposure to low levels of <br /> benzene (<100 ppm) has been reportea to result in blood _ <br /> abnormalities in humans , including anemia and, in rare cases , <br /> leukemia. These effects may develop over months or years without <br /> warning symptoms . <br /> ********************* XII. REGULATORY INFORMATION <br /> GOVERNMENTAL INVENTORY STATUS : All components registered in accordance <br /> with TSCA, EINECS , AILS , and MITI . <br /> � DOT. <br /> Shipping Name: Benzene <br /> Hazard Class- Flammable liquid <br /> ID Number: UN 1114 <br /> Railroad STCC. 4908110 <br /> ERG Number- 27 <br /> Comment: RQ for Benzene l0lbs . a <br /> EEC LABEL CLASS . F T (R45 Rll R48 R23/24/25 S53 S16 S29 S44 ) <br /> US OSHA HAZARD COMMUNICATION STANDARD. Proauct assessea in accordance <br /> with OSHA 29 CFR 1910. 1200 and determined to be hazardous. <br /> RCRA INFORMATION The disposal of the unused product may be subject t= <br /> RCRA regulations per 40 CFR Part 261 for the reasons including bu_ <br /> not limited to ignitability, corrosivity, reactivity or formulatic-z <br /> with the contaminants listed in the Toxicity Characteristic (TC) <br /> Rule as determined by the Toxicity Characteristic Leaching Procedure <br /> (TCLP) Disposal of the used product may be regulated . <br /> BENZENE. 99 . 9616 PCT (TCLP) <br /> FLASH: 12 (-11) F(C) <br /> U.S . Superfund Amendments and Reauthorization Act (SARA) Title III : <br /> This product contains no "EXTREMELY HAZARDOUS SUBSTANCES" <br />