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u t l l
<br /> v
<br /> III^
<br /> IA 66
<br /> operat�arxs may
<br /> " gloves ` -and ciaczting Ire nor
<br /> direct dermal lcaatact
<br /> not
<br /> : :Orn. They ray c pratectxre
<br /> ' nhalazian e'caosures tra:a also e
<br /> , receiv
<br /> Cne more va lat�3.e caorteacs. ' smai?
<br /> 7 k5 F i
<br /> OO ' CIi 3 , , IIi Calls IZERATICNS,
<br /> 66.3. 1` ,�
<br /> Animal
<br /> } r, +i SttsdieS ,, roll „b
<br /> C , tr I, 11 t I
<br /> }kd,r� i4 Ci( ' tiv� i d ,daiM y�
<br /> , � u i 4
<br /> � I I CiarC�nag
<br /> , � ,qt. , ,
<br /> 4 9 do I 4, 7 4 i I
<br /> e7en Ceneril�LY ' rttmber' L";,and' numb ` 's y ? �'I , ^ f,, rid „
<br /> e ,t gh,)„ �- er ,2�zfual ails 'r'a r
<br /> arl haw tney F conta +N ;' £ Y� Ia tr r , �� T10Cr [a ,
<br /> 1 ti':t ,� ,+i rl r iA !e sat,^v �Sd >t ;Wn ,P^ 4 rcZYtG
<br /> ��trZal�'���£tials R ,.7.��„,„ ,,aroma<c�c`,,�hydrocsrbarts, (2219 •1 , eaic ,
<br /> -tj '4 Z a SiLV`hifl aT.s numbs Y' a3 Zm, Sat reS ` r Y�ti. Y13 contrast.
<br /> - tori Ic.tair ,' highly °condo �, firh � , I')” fir' it s i.dua.L oxIs which pracnssesk,� �YsThevraivE b edY r?romaCtc�', produ= s From ' severe 4fua
<br /> com�i nts ch' bo' ° �', a �csz 370 Qing
<br /> genla , `cc r animals if the contain, cr pAH
<br /> ott� 1 ab0 'e •e,c z2 n y
<br /> Certain;currartcly
<br /> " �aY arw,,"airiA'd �avariable. Eue1N'oilsl,�mav be "'carcinogenic becausz e
<br /> 'siC#t thasaa`}� ,from the'. blendrig 4aE fractions ba
<br /> r ,prboiiing ae,"lhigher',l eeazp Ling ` be Low )70•C
<br /> .ucis which, arc '' °f �„," , ercures. some of these
<br /> } war �r derived,E,fzomy k7 4 'e, ,1,I ,l 1,, i�.r h=gh-baxlin
<br /> Fn '
<br /> car cznagenarif(2'219,);: ; ? �a ,,,, ,_., ea�a Ycic,.cracking processes 'R '
<br /> 'y n S, Canca
<br /> rn t� t w,f'1i v � r11r ,�' r T of �4¢' nrti ,,P'�P'', ,,M , 'l ✓' 1S3
<br /> 'Y n�} L F o ° , � � /'nr• u r a �r," i I i�a I t^ ,� ,
<br /> ° 9 11,
<br /> t SCxtdiez','7hiv ll
<br /> e demons , r
<br /> �» _ �� traced
<br /> potency, 'andhe cote a ,;direr=t' relac�anshxg between
<br /> to form' 461' ceneira=tan aEr high=bail`in ti` ax R1� , v tumor
<br /> �, rI, F - �G, vaSide T $,fractions which are
<br /> Of 700 t cermined k ��O , f 4 added
<br /> �;F'7 ,I1caCa'L t: + h� �rs� L „ a I�IaC!fVt1�rY`<nOc more , Ch3il '10 'VOiLltae
<br /> Pocetieyk rV ' y' �•fd$aSj ox1 oz.,
<br /> r Cl'2r1£fed0i1 ` L's ''p=!'Sent• Che��
<br /> aluesa o f>>
<br /> w ` bOrQerline�Ire 5� ti�ChQ, �bb1lndS ar;e R �� r IrsNa� �# a G at r
<br /> - , W - �significariee;�'`"Tlie < .. _ T <!Lass chanV 20-3 artd 'kiherefo' have '
<br /> of �he� �Iumor' - ;' � rumor
<br /> faizaation� r potency ,value Ls `a representation
<br /> a r'value ot��2q,I rl ace ;in response, co applIca ci`on" r-O mouse' skin
<br /> t ear a
<br /> (tali)r, 500 davs would,'be required fc=`-a.c 501 cumor' response
<br /> (see Table 66-4) Examination, o_f, boLling ranges of bienaed
<br /> pecraleum products Raw
<br /> carcinogen., noc-Tprovide an accurate asaessiaentI of their
<br /> pacettcxal. In the "p -on of rBingnam ec al. (2219) , these
<br /> Qaterials
<br /> are probably carcinngeiliC and` theL]C pocencv rasv be
<br /> ` dereStimac&d or,
<br /> 'overescimaced L f the hd
<br /> or Lrihzbi -ars,. iluent contains "cocarcinogen$
<br /> N `. sr. t 1 , N
<br /> , ,
<br /> „ Frazier and Mahluia
<br /> oil 'blanc ( 1819) tested the'lLnZtlaciart accivxt-� of a Euel
<br /> "f ,(FOB) 1nxch contaxned
<br /> els_-0 Oar-e1,boxlin r' _ part oE_ a heavy moiecular wexghc -i
<br /> r 6 , at 288-454•C and 2.9 parts of a dxstillace balling
<br /> between 17I and 288,o,C The - FOA t
<br /> backs o t "C-0 raxce Ln a 50 uL volume mg? sas applied co cite c lippeo a
<br /> artzmais cecexved doses of 5 Two weeks after Lnir-iacion the
<br /> acetone cuxce veeici µg phorboL Ryristace acetate Ln 54
<br /> aceconey. Y for 24 weeks Negative controls were creacad vetch
<br /> Positive controls were Lnitiaced uLch,
<br /> (BAP) or dimechylbettzartettracene 50 �g benzo( a(pyrene }
<br /> Lrutiaczng n active '"� (0 ) The FOB shoved signzficanc
<br /> days' Greater;', chan Approximately 60 tumors ,sere seen after
<br /> , , 200 tumors were -170
<br /> ,controls Hvdrotreaced FOR w observed Ln Che SAP -osxt- -e
<br /> vdrotzeatment as also tested .n cite same manner
<br /> biolo has been suggested as a possible method Ear .eductn¢
<br /> gical act_-rxty of coal-derives marerials .e chis g.oua aoour
<br /> 171
<br /> 6/87
<br /> Y
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