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t <br /> , r <br /> e an is ceveLODed a c:tat cf- L2 zu=rs. Faces cisstar-nearlag <br /> souse had an average of cumars_ Me hvdrotrPaeed FOB was <br /> czsted For promoctn acc,:i�; also <br /> 3' In these studies rice were 50 I:placed <br /> -`t-h kg flKBA. after 2 .ee►cs chev were aromoced t--:tce weeKiv <br /> -eats w1 g 50 KL of a 1.3 <br /> control gsoiutian of hvdrotrt <br /> eaced FOB in acetone the <br /> razer zeas treacea -"Ch acetone Ear 2 tteekz and simLlaxly _ <br /> promoted W-Lrh C!7.P- hydrotreated FOB- "' The hvdro£reaced FOB possessed <br /> aeisurable tumor promoczn3 ,, acCLvlCv +'hen Cmik vas" used as the <br /> tniciator. 414A of the mice hada tumors- after__6 moncrts. Eachmouse had <br /> an average of 2 5 tumors '10 rumors were reported in ,mL+ceY created <br /> hvdracreaced FOB an nanin�ti°aced 4K eared etch <br /> ,r (acetone-'ore+^aced) I'skin <br /> 3.1.2 66 <br /> Kura A <br /> gettici'ty _ a <br /> FAP1 ", k ucredIN ,. .r ',} ar <br /> has cons `'a battery I o£ ',3 Cescs cof 'revaluate <br /> lautagenxc; o£, diesel` 1 rhe <br /> tY 'fuelp and 'number 2 ftlel?all"(19 <br /> Number 2 fuel oil caCalvcically 'crar-ked stock) gave rostt:--e <br /> results in each rest <br /> ` :n c:a Nees' assav LC vas judged to be eauivoczl <br /> ratter Chari negative because crie <br /> 5 relacLve1v high mutant frequencies in <br /> m °s Crain - rk98 were o3served4„ac 4 concencratians Tn a <br /> mouse lymphoma- assav”` - <br /> t <br /> as raucagenic 4 under acct arson „nes <br /> non-accivaeLonr conditions w ,c a cess concencrsclon o,f 1'_OO W Ng/rnL. ' cze <br /> ZtiClCign 'Erequencv vas,' 1`' , t1mes Chet saLvenc concral ai'chouc necabollc <br /> acclvaclon. In a-- rats bone marrow 'cytogenecLc` study, 5 rague-b�vlev <br /> rats, were adminiscerea '�`numoer 2 fuel 011 dissolved to Acorn ' oil by <br /> �,gavage ac dosages ranging E:oea 0 125 to 1.25` k dav' for 5 days The <br /> percencage of aberrant c'ells ranged from `$7 g/ <br /> 7 5 ca 1'_'.3 A h'Lgh <br /> ,pereencage of cells u{Ch chromatid breaks <br /> was seen ac* all creacmeetc <br /> levels.,_ Ia both cases ' the Increases Vere staczstically signLficant <br /> uadiv aCy�,Che', Lows "d highs dose, Levels} <br /> Diesel EueL gave negative results vraIn bock c�en • ` <br /> 1pnama as'siv and manse <br /> Posiclve+ Kaes r8sulcs were obr-ained In [he rat bone marrow <br /> crtoiperLcc assay The aiesel fuel -4as administered undiluted by <br /> ,:�-rapericor►eal Ind action Dose vas 0 6 ? 0 or 6 0 mL/kg/dav for L or <br /> days Single Ln)ectlons aC the mLd- or high-dose as well as the <br /> hign-dose -n the 5 dav prococol caused statistically significant <br /> increases In chromosome aonor�alLt_es X19141 <br /> } <br /> fb 3 1L 3 TeraeogenlcxC 2„bryoca.�ic_t-: ana Recroaucc-ve Effects <br /> One ceracolagy sruav of fuel oil was <br /> sconsored by API ' The found The s cudv -as <br /> �sacerlai used was <br /> SueClFlabeled fuel oiL” No <br /> icacxans ,-ere provir-ed From days n chrougn 15 of gestation <br /> p.e¢nant CRL_coBs CD(SD) RR rats -ere exposed CO airoorne concencxacions <br /> Of 0 86 9 or 408 4 ppm .or 5 hours dai1� '`. <br /> cerasere was no evidence of <br /> togenLCLty, zrabrvoca"ciciri' or Lnhibician of fecal grouch and <br /> deve topment ( 191.5) <br /> w <br /> 6/E7 <br /> , <br />