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"zL OILS b6-25 <br /> {R i <br /> =nlch is neur4LCXiC, rretiotain:.Lzs in mart. :ironic cepical atapllazcion <br /> of a solvent conra1.r%1.=z 35 21 n-hexane causea axonal sweLlLzzg arm <br /> =reLin dageneratzon Ln snicks. "o clLntc-- s;T.s we're seen. Dosaste. <br /> gas 1 g/kg/dav far 64 dews =n rabbitstopical appi1cazzoti of c-5'. <br /> aL./dav for up to 10 days causes redness,_ zzaa and scab f oxmatrlar�. <br /> Zt-hexane is neicher carc:nagenzc or 'teratogenic: A One ]:a, Ylvo studv iaa. <br /> rsts 'that wTinhaled, 2750 14pm for 5 days found an increased number—of— <br /> Chromosome che�bone ❑ax'rau^cells. No studies on <br /> Mutagenicity, reproductive caxictcv or cazcl-noseniciry in man were <br /> i t <br /> €ottt"la ( 12.1930 1°35)s ' ' , <br /> Octane <br /> y <br /> 8y� - the or`alz route', octane rally "tae amore taxis` than' ° Lma Lover <br /> homologues. Ti 'I.z Is A'aspira=ad ' iii=o the liiingz. it, may '`cause rapid <br /> death due to cardi}ac `arrest, raspzratarp paralyses and asphyxia. The <br /> narcotic poeencv of octans' is approximately chat,of hepearte buc ,Lc does <br /> not exhibit the CIS effects }seen with hexane or hefltane <br /> 1. <br /> In hu--ns zhe otily renorted effects, are iblLscartng and burning <br /> due co pro Longed skirt coi ntacc <br /> � <br /> In anxina°ls octane Ls a raucous memorane irrL::,anc. At hLgh <br /> concencracLons Lc* "`causes nircos'is. It is, expected" that savere <br /> exposure in humansg will' eproduce the ,same' effects. `lice exposed to <br /> vapor leve Ls of 22 ,000 ppm ­suffered respirator <br /> y arrest after 4 mxnutres <br /> of exposure 8_Yposure co 12 940 ppm for L85 minutes 'caused a decreased <br /> respzracory rate followed 'by death within 24"hours. Ito narcosis was <br /> seen after 48- mjLntices `of exposure to ,5350 ppra (12.46. 1938) <br /> M ` <br /> Dodecane • _e <br /> K <br /> Dodecane is noc highly rGxic The lowest toxic dose Far mice Lz <br /> lI <br /> E;/kg when aamina.scered percu=aneausly for 22 weeks Dodecane Ls a <br /> pocenttator of skin cu=ortgenesis by benzo(a)pyrene It decreased the <br /> effective chresnotd dose by a factor of LO Dodecane and <br /> phenvldodecane applied topically to the progeny of rats treated with <br /> benzo4a)pyreine chrysene or benzo(1b)tr2.phenvLene on the seventeenth day <br /> of `gestation produced tutaors Ln offspring to addicionaL Lnformacion <br /> is available ( L2. 1937) <br /> rso erc2ne <br /> Isonencane is a CIPS depressant Effects may Laclude e'tht.laracion <br /> dLz=_cess headacne Loss of appecLce nausea confusion LnabilLry to <br /> do fa.ne wank a persiscanc caste of gasoline and in extreme cases Loss <br /> of consciousness rnhalatton of up to 500 ppm appears to have no <br /> effect on humans 'Very high" vapor concentrarions are Lrrita==& to <br /> Me skirl and eves Repeated or prolonged skin conzacz 1L11 dry and <br /> defat skin resul tLrig in LrrYzation and dernacit:z fie LC,, -n the <br /> mouse is esr:iraated to be LOQ4 mg/L ( 12) <br /> 6/87 1 <br />