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1 <br /> (MSDS: 731678) Page 8 of 10 <br /> Target Organ(s): In rats and mice exposed to 0, 75, 250, or 750 ppm ethyl benzene in a two <br /> year inhalation study there was mild damage to the kidney(tubular hyperplasia), liver(eosinophilic foci, <br /> hypertrophy, necrosis), thyroid (hyperplasia)and pituitary(hyperplasia). <br /> n-Hexane CAS# 110-54-3 <br /> Target Organ(s): Excessive exposure to n-hexane can result in peripheral_neuropathies. The <br /> initial symptoms are symmetrical sensory numbness and paresthesias of distal portions of the extremities. <br /> Motor weakness'is typically observed in muscles of the'toes and fingers but may also involve muscles of <br /> the arms,thighs and forearms. The onset of these symptoms may be delayed for several months to a year <br /> after the beginning of exposure. The neurotoxic properties of n-hexane are potentiated by exposure to <br /> methyl ethyl ketone and methyl isobutyl ketone. <br /> Prolonged exposure to high concentrations of n-hexane (>1,000 ppm) has resulted in decreased sperm count, <br /> and degenerative changes in the testes of rats but not those of mice. <br /> Acute Data: <br /> Gasoline: <br /> li Dermal LD50>5 mllkg (Rabbit) <br /> LC50> 4500 ppm (Rat) <br /> Oral LD50= 18.75 ml/kg. (Rat) <br /> 1, 2, 4-Trimethyl Benzene: <br /> �• Dermal LD50= No data available <br /> LC50= 18 gmlm3/4hr (Rat) <br /> Y Oral LD50 = 3-6 g/kg (Rat) <br /> ilr Benzene: <br /> Dermal LD50> 9400 mg/kg (Rabbit), (Guinea Pig) <br /> LC50= 9980 ppm (Mouse); 10000 ppm/7hr. (Rat) <br />' Oral LD50=4700 mg/kg (Mouse); 930 mg/kg (Rat); 5700 mg/kg (Mammal) <br /> Cyclohexane: <br /> Dermal LD50=>2g/kg (Rabbit) <br /> LC50>4,044 ppm (4-hr., Rat) <br /> Oral LD50> 2g/kg (Rat) <br /> } . Ethyl Benzene: <br /> 4 Dermal LD50= 17800 mg/kg (Rabbit) <br /> LC50=4000 ppm/4 hr.; 13367 ppm (Rat) <br /> Oral-LD50=3500 mg/kg (Rat) <br /> n-Hexane: <br /> Dermal LD50=>2,000 mg/kg (Rabbit) <br /> LC50>3,367 ppm (4-hr., Rat) <br /> Oral LD50>5,000 mg/kg (Rat) <br /> Toluene:. <br /> Dermal LD50= 14 g/kg (Rabbit) <br /> LC50 = 8,000 ppm (4-hr., Rat) <br /> Oral LD50 =2.5-7.9 g/kg (Rat) <br /> Xylene.- <br /> Dermal <br /> ylene:Dermal LD50 >3.16 ml/kg (Rabbit) <br /> LC50= 5000 ppm/4 hr. (Rat) <br /> Oral LD50 =4300 mg/kg (Rat) <br /> -12. ECOLOGICAL INFORMATION. <br /> II <br />