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(MSDS: 731678) Page 8 of 10 <br /> _ Target Organ(s): In rats and mice exposed to 0, 75, 250, or 750 ppm ethyl benzene in a two <br /> year inhalation study there was mild damage to the kidney(tubular hyperplasia), liver(eosinophilio foci, <br /> hypertrophy, necrosis),thyroid (hyperplasia)and pituitary(hyperplasiA). <br /> n-Hexane (CAS# 110-54-3) <br /> Target Organ(s): Excessive exposure to n-hexane can result in peripheral neuropathies. The <br /> initial symptoms are symmetrical sensory numbness and paresthesias of distal portions of the extremities. <br /> Motor weakness is typically observed in muscles of the toes and fingers but may also involve muscles of <br /> the arms, thighs;and forearms. The onset of these symptoms may be delayed for several months to a year <br /> after the beginning of exposure. The neurotoxic properties of n-hexane are potentiated by exposure to <br /> methyl ethyl ketone and methyl isobutyl ketone. <br /> Prolonged exposure to high concentrations of.n-hexane ( 1,000 ppm)has resulted in decreased sperm count . <br /> and degenerative changes in the testes of rats but not those of mice. . <br /> Acute Data: <br /> Gasoline: <br /> Dermal LD50>5 ml/kg (Rabbit) <br /> LC50> 4500 ppm (Rat) <br /> Oral LD50= 18.75 ml/kg. (Rat) <br /> 1, 2, 4-Trimethyl:Benzene:, <br /> Dermal LD50= No data available <br /> LC50 = 18 gm/m3/4hr (Rat) <br /> Oral LD50 =3-6 g/kg (Rat) <br /> Benzene: <br /> Dermal LD50> 9400 mg/kg (Rabbit), (Guinea Pig) <br /> LC50= 9980 ppm (Mouse); 10000 ppm/7hr.(Rat) <br /> Oral LD50=4700 mg/kg (Mouse);930 mg/kg (Rat); 5700 mg/kg(Mammal) <br /> Cyclohexane: <br /> . Dermal LD50=>2g/kg (Rabbit) <br /> LC50>4,044 ppm (4-hr., Rat) <br /> Oral LD50>2g/kg (Rat) <br /> Ethyl Benzene: <br /> Dermal LD50= 17800 mg/kg (Rabbit) <br /> LC50=4000 ppm/4 hr.; 13367 ppm (Rat) <br /> r_ Oral LD50=3500 mg/kg (Rat) <br /> Ln-Hexane: <br /> Dermal LD50=>2,000 mg/kg(Rabbit) <br /> LC50>3,367 ppm (4-hr., Rat) <br /> Oral LD50>5,000 mg/kg (Rat) <br /> Toluene: <br /> Dermal LD50= 14 glkg (Rabbit) <br /> LC50 =8,000 ppm (4-hr., Rat) <br /> Oral LD50 =2.5-7.9 g/kg (Rat) <br /> Xylene: <br /> Dermal LD50>3.16 ml/kg (Rabbit) <br /> LC50= 5000 ppm/4 hr. (Rat) <br /> Oral LD50 =4300 mg/kg (Rat) <br /> y `. 12. ECOLOGICAL INFORMATION <br />