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N (MSDS: 731678) Page 7 of 10 Because solvent extracts of gasoline exhaust particulates caused skin cancer in laboratory animals, IARC has categorized gasoline engine exhaust as a possible human cancer hazard. l Target Organ(s): A two year inhalation study of wholly vaporized unleaded gasoline produced nephropathy in male rats, characterized by the accumulation of alpha-2-u-globulin in epithelial cells of the proximal tubules, and necrosis and hyperplasia of surrounding cells. Follow-up studies have demonstrated that these changes are unique to the male rat. Although prolonged exposure to n-hexane,'a component of gasoline,has resulted in adverse male' reproductive effects in experimental animal studies, no adverse male reproductive effects were found in studies conducted with gasoline. Developmental: No evidence'of developmental toxicity was found in pregnant laboratory animals l..i (rats and mice) exposed to up to 9,000 ppm vapor of unleaded gasoline via inhalation. J Xylenes (CAS#-1330-20-7) Target Organ(s): A six week inhalation study with xylene produced hearing loss in rats. Developmental: Both mixed xylenes and the individual isomers produced limited evidence of developmental toxicity in laboratory animals. Inhalation and oral administration of xylene resulted in decreased fetal weight, increased incidences of delayed ossification, skeletal variations and resorptions. Toluene tCAS# 108-88-3 Target Organ(s): Epidemiology studies suggest that chronic occupational overexposure to, toluene may damage color vision. Subchronic and chronic inhalation studies with toluene produced kidney and liver damage, hearing loss and central nervous system (brain)damage in laboratory animals.. Intentional misuse by deliberate inhalation of high concentrations of toluene has been shown to cause diver, kidney, and central nervous system damage, including hearing loss and visual disturbances. �_ ~.. . Developmental: Exposure to toluene during pregnancy has demonstrated limited evidence of developmental toxicity in laboratory animals. The effects seen include decreased fetal body weight and increased skeletal variations in both inhalation and oral studies. Benzene CAS#71-43-2] Carcinogenicity: Benzene is an animal carcinogen and is known to produce acute myelogenous leukemia (a form of cancer)in humans. Benzene has been identified as a human carcinogen,by NTP, [ARC and OSHA. Target Organ(s): Prolonged or repeated exposures to benzene vapors has been linked to bone. marrow toxicity which can result in blood disorders such as leukopenia, thrombocytopenia, and aplastic anemia. All of these diseases can be fatal. Developmental: Exposure to benzene during pregnancy demonstrated limited evidence of developmental toxicity in laboratory animals. The effects seen include decreased body weight and increased skeletal variations in rodents. Alterations in hematopoeisis have been observed in the fetuses and offspring of pregnant mice. Mutagenicity: Benzene exposure has resulted in chromosomal aberrations in human lymphocytes and animal bone marrow cells, and DNA damage in mammalian cells in vitro. Ethyl Benzene CAS# 100-41-4 Carcinogenicity: Rats and mice exposed to 0, 75,250,or 750 ppm ethyl benzene in a two year inhalation study demonstrated limited evidence of kidney, liver,and lung cancer. Ethyl benzene has been listed as a possible human carcinogen by[ARC. Ethyl benzene has not been listed as a carcinogen by NTP, or OSHA. r