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CYCOMO 5276-1 Structural Prepreg SDS: 0009706 Date Prepared: 02/05/2017 Page 7 of 11
<br /> HAZARDOUS INGREDIENT TOXICITY DATA
<br /> Based on data generated on a structurally similar material, Amine compound#2, has estimated acute acute oral (rabbit)
<br /> and acute dermal (rabbit)and LD50 values of>600-1500 mg/kg and >2000 mg/kg, respectively. After acute oral
<br /> exposure this substance is likely to produce methemoglobinemia. Direct contact with this material is not expected to
<br /> produce skin irritation. This material is not expected to produce dermal sensitization. A 90-day repeated dose toxicity
<br /> study was conducted (with a structurally similar material) in male and female rats. The animals were dosed via oral
<br /> gavage at nominal dose levels of 0, 3, 30 and 100 mg/kg bw/day. Treatment-related findings were observed at 30
<br /> mg/kg/day.The main effects were cyanosis of the skin (dapsone is known to induce methemoglobinemia, and the
<br /> cyanosis may be secondary to this), hyperactivity, increased WBC count, decreased RBC count, hemoglobin
<br /> concentration and hematocrit., increased prothrombin time, spleenomegaly(especially in males), mild spleenic
<br /> congestion, and mild pigmentation of the spleen.These effects were more pronounced at 100 mg/kg/day. No frank
<br /> toxicity was observed at 3 mg/kg/day, although minimal brown pigmentation of the spleen was observed. Therefore, 3
<br /> mg/kg/day is considered as the NOAEL in this study. In a Prenatal Developmental Toxicity Study,with a structurally
<br /> similar material, mice were dosed by oral gavage at levels of 0, 50, 100 and 200 mg/kg bw/day. Maternal mortality(10%)
<br /> was noted at the high dose, but otherwise clinical observations were unremarkable.At scheduled necropsy, gross
<br /> findings included enlarged spleens in 1, 12, 13 or 17 dams in the control through high dose groups, respectively.
<br /> Matemal body weight, weight change, and gravid uterine weight were each reduced at the highest dose of 200
<br /> mg/kg/day. Based on these read-across results, Amine compound#2 is not considered to be teratogenic. This
<br /> substance is not expected to be mutagenic/genotoxic or clastogenic in the Ames Assay, Mouse Lymphoma Assay, in
<br /> vitro Chromosomal Aberrations Assay or in the in vivo Mouse Micronucleus Assay.
<br /> Epoxy/Phenolic resin has acute oral (rat)and dermal (rabbit) LD50 values of>2000 mg/kg and 4000 mg/kg, respectively.
<br /> Direct contact may cause mild eye irritation. Prolonged or repeated dermal exposure may cause irritation. This material
<br /> may cause allergic skin reactions in rare instances. This polymer has been reported to have tested positive for
<br /> mutagenicity in the standard Ames screening test as well as in a mouse lymphoma cell point mutation assay.
<br /> Fiberglass is considered a nuisance particulate which will not cause adverse health effects other than respiratory
<br /> congestion or irritation.
<br /> Overexposure to fused silica fiber by inhalation, oral or dermal route is not expected to cause adverse effects.
<br /> Amorphous silica does not cause the lung disease that crystalline silica is known to cause. The acute oral (rat) LD50
<br /> value for silica is>7.5 g/kg and the L050 in rats exposed via inhalation is>250 mg/m'.
<br /> Phenol, polymer with 3a,4,7,7a-tetrahydro-4,7-methano-1 H-indene, glycidyl ether has an acute oral (rat) LD50 value of
<br /> >2000 mg/kg. This material did not produce significant skin or eye irritation when tested with in vitro models. This material
<br /> did not produce dermal sensitization when tested in guinea pigs. Positive results from an in vivo mammalian alkaline
<br /> comet study supported by positive results from in vitro mutagenicity assays or chemical structural activity relationships to
<br /> know germ cell mutagens leads to the conclusion that this substance is suspected genetic defects.
<br /> p-(Diglycidylamino)phenyl glycidyl ether, has acute oral (rat)and dermal (rat) LD50 values of 1000 mg/kg and 4000
<br /> mg/kg, respectively. Direct contact with this material caused marked skin irritation when tested in rabbits. This material
<br /> also caused skin sensitization when tested in guinea pigs. This material was found to be positive in various mutagenicity
<br /> tests including the Ames test, mouse lymphoma test and the sister chromatid exchange. This material causes eye
<br /> irritation.
<br /> Carbon fibers may cause mechanical irritation of the eyes, skin, nose and throat. Airborne carbon fibers are not
<br /> considered respirable.A typical carbon fiber may be characterized as having a diameter of 5-7 microns and a length
<br /> greater than 100 microns. Fibers with diameters greater than 3.5 microns are not considered respirable.
<br /> California Proposition 65 Warning (applicable in California only)-This product contains(a)chemical(s) known to the State
<br /> of California to cause cancer and birth defects or other reproductive harm.
<br /> 12. ECOLOGICAL INFORMATION
<br /> TOXICITY, PERSISTENCE AND DEGRADABILITY, BIOACCUMULATIVE POTENTIAL, MOBILITY IN SOIL,OTHER
<br /> ADVERSE EFFECTS
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