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Final Release LLNL Site 300 (USDOE) If additional information concerning potential exposures or off-site contaminant concentrations becomes available that potentially changes our public health findings, ATSDR will reevaluate the potential for adverse health effects from LLNL Site 300-specific sources or releases. Comment: The PHA does not consider current health data in the Tracy community. There are many cancer victims in and around Tracy. Tracy has an elevated inhalation cancer risk that is three times the California State average. Response: The public health assessment process involves two primary scientific evaluations the exposure evaluation and the health effects evaluation. The exposure evaluation is always performed first to determine how much contamination is at a site, where it is, and how people might come into contact with it. If a completed exposure pathway exists, a further, more in-depth analysis will be performed, often including a health effects evaluation. If the exposure evaluation concludes that people have or could have been exposed to site-related hazardous substances, ATSDR scientists will determine whether these exposures may result in harmful effects. Data collected in the health effects evaluation can include results of medical, toxicological and epidemiological studies and data collected in disease registries. At Site 300, ATSDR scientists determined that there were no completed exposure pathways. This simply means that,based on currently available data, no one has been or is currently being exposed to contaminants related to Site 300 activities. Since exposure has not occurred,pursuing an in-depth investigation of health data of residents in the Tracy community is unnecessary. Comment: LLNL has recently proposed a new cleanup plan—the Risk Based End States Vision—that proposes to lower cleanup standards and limits on-site cleanup. Response: See the Response to the Comments under the Remedial Activities—Funding and Timeframe section of Appendix A. The Risk Based End States Vision is a proposal for clean-up activities at Site 300 that are based upon and driven by human and ecological risk receptors. It describes projected site conditions 20 years into the future and assumes that current remediation strategies already in place have worked effectively over this time period. This means that off-site contamination will have been reduced to levels that allow unrestricted use of groundwater, and on-site contamination will have been reduced to a level that prevents further contaminated groundwater migration off-site. Once this B-2