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EXTOXNET Extension Toxicology Network Pesticide Information Profiles A Pesticide Information Project of Cooperative Extension Offices of Cornell University, Oregon State University, the University of Idaho, and the University of California at Davis and the Institute for Environmental Toxicology, Michigan State University. Major support and funding was provided by the USDA/Extension Service/National Agricultural Pesticide Impact Assessment Program. EXTOXNET primary files maintained and archived at Oregon State University Revised June 1996 Oxyfluorfen Trade and Other Names: Trade names include Goal, Koltar and RH-2915. Regulatory Status: Oxyfluorfen is a slightly to practically non-toxic compound in EPA toxicity class 11I [2]. Products containing oxyfluorfen must bear the Signal Word WARNING on the label because some formulated products may have higher toxicities. It is a General Use Pesticide (GUP). Chemical Class: Not Available I� Introduction: Oxyfluorfen is a selective pre- and post-emergent herbicide used to control certain annual broadleaf and grassy weeds in vegetables, fruit, cotton, ornamentals, and on non-crop areas (e-g. rail- and highway right-of-ways). It is a contact herbicide and light is required for it to affect target plants. It is available in emulsifiable concentrate and granular formulations. Formulation: It is available in emulsifiable concentrate and granular formulations. Toxicological Effects: • Acute toxicity: Oxyfluorfen is practically nontoxic by ingestion, with reported oral LD50 values of 5000 mg/kg in both rats and dogs, and 2700 to 5000 mg/kg in mice [1,58]. The dermal LD50 is greater than 5000 mg/kg in both rats and rabbits, also indicating slight toxicity by this route [58]. It causes no skin irritation in rabbits, no skin sensitization in guinea pigs, and moderate eye irritation in rabbits [58]. However, Goal and other formulations may show severe skin and eye irritant properties, and may be skin sensitizers [58]. The 4-hour inhalation LC50 for the technical product is not available, but that for Goal 1.6E is greater than 22.64 mg/L, indicating practically no toxicity via this route [58]. • Chronic toxicity: Effects on the liver have been observed in long-term feeding studies with rats, mice, and dogs [56,108]. • Reproductive effects: In a developmental study'with rats given doses of 10, 100, or 1000 mg/kg/day by gavage, decreased implantation, increased resorption, and lower fetal survival was seen at the 1000 mg/kg level. Toxic effects on the mothers were also seen at this dose [108]. At