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EXTOXNET PIP - DIFLUBENZURON Page 1 of 3 EXTOXNET Extension Toxicology Network Pesticide Information Profiles i ' A Pesticide Information Project of Cooperative Extension Offices of Cornell University, Oregon State University, the University of Idaho, and the University of California at Davis and the Institute for Environmental Toxicology, Michigan State University. Major support and funding was provided by the USDA/Extension Service/National Agricultural Pesticide Impact Assessment Program. EXTOXNET primary files maintained and archived at Oregon State University y ' Revised June 1996 ,biflubenzuron�* Trade and Other Names: Diflubenzuron is sold under the trade name-Dimilin.,Other trade names inlcude DUI 12307, ENT-29054, Micromite, and OMS-1804. Re9ulato Status: Some formulations of diflubenzuron may be classified as Restricted Use Pesticides (RUPs) in the U.S. RUPs may be purchased and used only by certified applicators. Diflubenzuron is classified as toxicity class III - slightly toxic. Products containing it bear the Signal Word CAUTION. Chemical Class: benzoylphenylurea Introduction: Diflubenzuron is a benzoylphenyl urea used on forest and field crops to selectively control insects and parasites. Principal target insect species are the gypsy moth, forest tent caterpiller, several evergreen eating moths, and the boll weevil. It is also used as a larvae control chemical in mushroom operations and animal houses. Diflubenzuron is a stomach and contact poison. It acts by inhibiting the production of chitin, a compound that makes the outer covering of the insect hard and thus interferes with the formation of the insect's cuticle or shell. It is available as a suspension concentrate, wettable powder, or in granules. Formulation: It is available as a suspension concentrate, wettable powder, or in granules. Toxicological Effects: . Acute toxicity: No overt signs of toxicity were observed in any of the acute studies conducted [16]. The oral LD50 in rats and mice is greater than 4640 mg/kg, and the dermal LD50 is greater than 10,000 mg/kg in rats and greater than 4000 mg/kg in rabbits. It is nonirritating to skin and slightly irritating to eyes [8]. . Chronic toxicity: Rats given moderate amounts of the compound for 2 years had enlarged spleens, while E mice in a similar study had liver and spleen enlargement at slightly lower levels of exposure. In a study with cats fed over a wide range of doses for 21 days, all of the females had dose related blood chemistry changes at low doses and the males exhibited changes at dose levels that were slightly higher [9]. The changes were reversible. The chemistry changes were associated with the formation of methemoglobin, a form of hemoglobin that is unable to carry oxygen. . Reproductive effects: Day-old ducks and turkeys fed moderate amounts of the pesticide in their diets for 90 days had decreased testosterone levels after 42 days, but this did not occur in chickens and pheasants in the same study. Combs and wattles,which reflect hormone activity, showed some abnormalities. Some were + underdeveloped and others more developed compared to controls. A short-term decrease in testosterone levels { was shown in the sexually immature rats but no clear cut change was shown in young bull calves [16]. A