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EXTOXNET PIP - MANCOZEB Pagel of 3
<br /> EXTOXNET
<br /> Extension Toxicology Network
<br /> Pesticide Information Profiles
<br /> A Pesticide Information Project of Cooperative Extension Offices of Cornell University, Oregon State University, the
<br /> University of Idaho, and the University of California at Davis and the Institute for Environmental Toxicology, Michigan
<br /> State University. Major support and funding was provided by the USDA/Extension Service/National Agricultural
<br /> Pesticide Impact Assessment Program.
<br /> EXTOXNET primary files maintained and archived at Oregon State University
<br /> Revised June 1996
<br /> Mancozeb
<br /> Trade and Other Names: Trade names include Dithane, Dithane-Ultra, Fore, Green-Daisen M, Karamate,
<br /> Mancofol, Mancozeb, Mancozin, Manzate 200, Manzeb, Manzin Nemispor,Nemispot, Policar, Riozeb, and Zimaneb.
<br /> Regulatory status: Mancozeb is a practically nontoxic ethylene bisdithiocarbamate in EPA toxicity class IV -
<br /> practically nontoxic. It is registered as a General Use Pesticide (GUP). Labels for products containing mancozeb must
<br /> bear the Signal Word CAUTION.
<br /> Chemical Class: ethylene(bis) dithiocarbamate
<br /> Introduction: Mancozeb is used to protect many fruit, vegetable, nut and field crops against a wide spectrum of fungal
<br /> diseases, including potato blight, leaf spot, scab (on apples and pears), and rust (on roses). It is also used for seed
<br /> treatment of cotton,potatoes, corn, safflower, sorghum,peanuts, tomatoes, flax, and cereal grains. Mancozeb is available
<br /> as dusts, liquids, water dispersible granules, as wettable powders, and as ready-to-use formulations. It may be commonly
<br /> found in combination with zineb and maneb.
<br /> Formulation: Mancozeb is available as dusts, liquids,water-dispersible granules, wettable powders, and ready-to-use
<br /> formulations. It is commonly found in combination with zineb and maneb.
<br /> Toxicological Effects:
<br /> • Acute toxicity: Mancozeb is practially nontoxic via the oral route with reported oral LD50 of greater than 5000
<br /> mg/kg to greater than 11,200 mg/kg in rats [1,3]. Via the dermal route it is practically nontoxic as well, with
<br /> reported dermal LD50 values of greater than 10,000 mg/kg in rats, and greater than 5000 mg/kg in rabbits [4]. It is
<br /> mild skin irritant and sensitizer, and a mild to moderate eye irritant in rabbits [4,32]. Workers with occupational
<br /> exposure to mancozeb have developed sensitization rashes [I].
<br /> • Chronic toxicity: No toxicological effects were apparent in rats fed dietary doses of 5 mg/kg/day in a long-term
<br /> study [1]. Impaired thyroid function was observed as lower iodine uptake after 24 months in dogs fed doses of 2.5
<br /> http://extoxnet.orst.edu/pips/mancozeb.htm -4�'3/13/200f
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