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EXTOXNET PIP- IPRODIONE Pagel of 3 EXTOXNET Extension Toxicology Network Pesticide Information Profiles A Pesticide Information Project of Cooperative Extension Offices of Cornell University, Oregon State University, the University of Idaho, and the University of California at Davis and the Institute for Environmental Toxicology, Michigan State University. Major support and funding was provided by the USDA/Extension Service/National Agricultural Pesticide Impact Assessment Program. EXTOXNET primary files maintained and archived at Oregon State University Revised June 1996 Iprodione Trade and Other Names: Trade names for commercial products containing iprodione include Chipco 26019, DOP 500F, Kidan, LFA 2043, NRC 910, Rovral, and Verisan. The compound is used in formulations with numerous other fungicides such as thiabendazole and carbendazim. It is compatible with most other pesticides. Regulatory Status: Iprodione is a slightly toxic compound and products containing it cavy the Signal Word CAUTION on the label. Most products containing iprodione are General Use Pesticides (GUPs). Chipco 26019 and Rovral (under some circumstances) may be Restricted Use Pesticides (RUPs). RUPs may be purchased and used only by certified applicators. Chemical Class: dicarboximide Introduction: Iprodione is a dicarboximide contact fungicide used to control a wide variety of crop diseases. It is used on vegetables, ornamentals, pome and stone fruit, root crops, cotton, and sunflowers to control fungal pests, and may also be used as a post harvest fungicide and as a seed treatment. Iprodione inhibits the germination of spores and the growth of the fungal mat (mycelium). Formulation: Not Available Toxicological Effects: • Acute toxicity: Iprodione is slightly toxic by ingestion, with reported oral LD50 values of 3500 mg/kg in rats, 4000 mg/kg in mice, and greater than 4400 mg/kg in rabbits [1,8]. No dermal toxic effects were noted at doses of over 2500 mg/kg in the rat and at 1000 mg/kg in the rabbit, indicating slight toxicity by this route [1,8]. Inhalation toxicity is also low for this compound. The 4-hour inhalation LC50 for iprodione is greater than 3.3 mg/L in the rat [8]. • Chronic toxicity: Rats given dietary doses of approximately 60 mg/kg/day over 1 1/2 years suffered no ill effects [1,8]. Dogs fed approximately 60 mg/kg/day over 18 months also showed no adverse effects [1,8]. In another study, http://extoxnet.orst.edu/pips/iprodion.htm 3/26/2007