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EXTOXNET PIP -ZIRAM Page 1 of 4 lt*.e e/ EXTOXNET Extension Toxicology Network Pesticide Information Profiles A Pesticide Information Project of Cooperative Extension Offices of Cornell University, Oregon State University, the University of Idaho, and the University of California at Davis and the Institute for Environmental Toxicology, Michigan State University. Major support and funding was provided by the USDA/Extension Service/National Agricultural Pesticide Impact Assessment Program. EXTOXNET primary files maintained and archived at Oregon State University Revised June 1996 Ziram Trade and Other Names: Trade names for products containing ziram include AAprotect, AAvolex, Antene, Attivar, Carbazinc, Corozate, Cuman, Drupine, Fuklasin,Fungostop, Mezene, Milbam, Pomarsol Z Forte, Prodaram, Tricarbamix, Triscabol, Z C Spray, Zerlate, Zincmate, Zinkcarbamate, Ziram,Zirasan,Zirbeck and Zirex. The compound may be found in formulations with other fungicides such as bitertanol, dodine, myclobutanil, thiram, and zineb. Regulatory Status: Ziram is a General Use Pesticide(GUP)in the U.S. Ziram is a slightly to moderately toxic compound, EPA toxicity class III. Ziram carries the Signal Word DANGER on its label due to eye irritation hazard. Chemical Class: dithiocarbamate Introduction:Ziram is an agricultural dithiocarbamate fungicide used on a wide variety of plant fungi and diseases. It may be applied to the foliage of plants, but it is also used as a soil and/or seed treatment. Ziram is used primarily on almonds and stone fruits. It is also used as an accelerator in rubber manufacturing,packaging materials, adhesives, and textiles. Another use of the compound is as a bird and rodent repellent. Ziram is often marketed as a wettable powder or as granules. Granules or grains are sifted into water and agitated prior to application. Formulation: Ziramis often marketed as a wettable powder or as granules. Granules or grains are sifted into water and agitated prior to application. Toxicological Effects: . Acute toxicity: Acute exposure among industrial and farm workers in the former U.S.S.R. caused irritation of the skin, nose, eyes, and throat [1]. The oral LD50 for ziram is 1400 mg/kg in rats and 480 and 400 mg/kg in mice and rabbits, respectively. Ziram has an LD50 of 100 to 150 mg/kg in guinea pigs [4]. The acute dermal LD50 in rats is greater than 6000 mg/kg. Ziram is corrosive to eyes and may cause irreversible eye damage [43]. . Chronic toxicity: Female rats administered relatively small doses of ziram in their diets (2.5 mg/kg/day) for 9 months showed decreased antibody formation. Rats fed doses of 1 to 2 mg/kg/day ziram for an unknown time http://extoxnet.orst.edu/pips/ziram.htm