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EXTOXNET PIP - MOLIN�E .woe Page 1 of 3 <br /> EXTOXNET <br /> Extension Toxicology Network <br /> Pesticide Information Profiles <br /> A Pesticide Information Project of Cooperative Extension Offices of Cornell University, Oregon State <br /> University, the University of Idaho, and the University of California at Davis and the Institute for <br /> Environmental Toxicology, Michigan State University. Major support and funding was provided by the <br /> USDA/Extension Service/National Agricultural Pesticide Impact Assessment Program. <br /> EXTOXNET primary files maintained and archived at Oregon State University <br /> Revised June 1996 <br /> Molinate <br /> Trade and Other Names: Trade names include Hydram, Molinate, Ordram, and Yalan. <br /> Regulatory Status: Molinate is a slightly to moderately toxic compound in EPA toxicity class III, <br /> and is a registered as a General Use Pesticide (GUP). Products containing molinate must bear the Signal <br /> Word WARNING or CAUTION. <br /> Chemical Class: thiocarbamate <br /> Introduction: Molinate is a selective thiocarbamate herbicide used to control broad-leaved and <br /> grassy plants in rice and other crops. Molinate is available in granular and emulsifiable liquid <br /> formulations. <br /> Formulation: Molinate is available in granular and emulsifiable liquid formulations. <br /> Toxicological Effects: <br /> • Acute toxicity: Molinate is moderately toxic by ingestion with reported oral LD50 values of 369 <br /> to 720 mg/kg in rats, and 530 to 795 mg/kg in mice. Dermal LD50 values are 4000 to 4800 mg/kg <br /> in rats [3,7]. It is mildly irritating to rabbit skin and moderately irritating to rabbit eyes, and is not <br /> a skin sensitizer [7]. The 4-hour inhalation LC50 of 1.36 mg/L indicates moderate toxicity by this <br /> route as well [4]. Some formulations show a lower degree of acute toxicity [6,7]. Symptoms of <br /> exposure to molinate include nausea, diarrhea, abdominal pain, fever, weakness, and <br /> conjunctivitis [7,13]. <br /> • Chronic toxicity: The only reported human exposure to molinate resulting in adverse health <br /> effects comes from a report of well contamination in Japan. After field application of <br /> approximately 60 kg active ingredient to a 2-hectare rice paddy, several people noticed an odor <br /> emitted from a nearby well, and fell ill as a result of repeated consumption of water from that well <br /> http://cxtoxnct.orst.edu/pips/molinate.htm 9/21/2004 <br />