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EXTOXNET PIP - LAMBD.rCYHALOTHRIN Page 1 of 4 EXTOXNET Extension Toxicology Network Pesticide Information Profiles A Pesticide Information Project of Cooperative Extension Offices of Cornell University, Oregon State University, the University of Idaho, and the University of California at Davis and the Institute for Environmental Toxicology, Michigan State University. Major support and funding was provided by the USDA/Extension Service/National Agricultural Pesticide Impact Assessment Program. EXTOXNET primary files maintained and archived at Oregon State University LAMBDA CYHALOTHRIN TRADE OR OTHER NAMES: Trade names for products containing lambda cyhalothrin include Charge, Excaliber, Grenade, Hallmark, Icon, Karate, Matador, OMS 0321, PP321, Saber, Samurai and Sentinel (62, 12). REGULATORY STATUS: Lambda cyhalothrin is a Restricted Use Pesticide and so may be purchased and used only by certified applicators (62, 12). It is in EPA Toxicity Class II, and products containing it must bear the signal word WARNING (106). INTRODUCTION: Lambda cyhalothrin is a synthetic pyrethroid insecticide and acaricide used to control a wide range of pests in a variety of applications. Pests controlled include aphids, Colorado beetles and butterfly larvae (12). Crops on which it may be applied include cotton, cereals, hops, ornamentals, potatoes, vegetables or others (12). It may also be used for structural pest management or in public health applications to control insects such as cockroaches, mosquitoes, ticks and flies which may act as disease vectors (12). Lambda cyhalothrin is available as an emulsifiable concentrate, wettable powder or ULV liquid (62, 12), and is commonly mixed with buprofezin, pirimicarb, dimethoate or tetramethrin (12). It is compatible with most other insecticides and fungicides (12). Unless otherwise stated, data presented herein refer to the technical product. TOXICOLOGICAL EFFECTS . Acute Toxicity: Lambda cyhalothrin is moderately toxic in the technical form, but may be highly toxic via some routes in formulation (e.g., as Karate). Available data indicate that lambda cyhalothrin is moderately toxic via the oral route in test animals. Reported oral LD50 values are 79 mg/kg and 56 mg/kg for male and female rats, respectively (12, 107). The vehicle used was corn oil. The rat oral LD50 has also been reported as 144 mg/kg (108). The reported rat LD50 for the technical product is similar, 64 mg/kg (107). These indicate moderate acute toxicity via the oral route of exposure. No data were available regarding the acute toxicity of the technical compound via the inhalation route, but for Karate the reported 4-hour inhalation LC50s were 0.175 mg/L and 0.315 mg/L for female and male rats, respectively (107). These data indicate a moderate to high toxicity via the inhalation route for the formulated product Karate. The technical product has reported dermal LD50s of 632 mg/kg and 696 mg/kg for male and female rats (vehicle used was propane-1,2-diol) (12, 107). It has also been found to be non-irritating to the skin of rabbits (12, 107) and non-sensitizing to the skin of guinea pigs (107) but may cause mild http://extoxnet.orst.edu/pips/lambdacy.htm 9/21/2004