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MATERIAL SAFETY DATA SHEET UPDATES AVAILABLE AT WWW.GREENBOOK.NET 2
<br /> enzyme induction. Thyroxine levels were increased at aquatic habitats of concern. In case of accidents in-
<br /> doses of 200 mg/kg and above. All of these effects volving environmental release of this product,please
<br /> were slight and reversible. The no-observed-effect- ! call the emergency number on page 1.
<br /> level (NOEL) was 40 mg/kg. In subacute inhalation
<br /> studies,rats were exposed to aerosol concentrations 13. DISPOSAL CONSIDERATIONS:
<br /> of metribuzin ranging from 31 to 745 mg/cubic meter WASTE DISPOSAL METHOD:Follow container label
<br /> for 6 hours/day,5 days/week for 3 weeks. Effects ob- instructions for disposal of wastes generated during
<br /> served included behavioral changes,decreased body use in compliance with the FIFRA product label. In
<br /> weight gains,liver enzyme induction and organ weight other situations, bury in an EPA approved landfill or
<br /> effects.The no-observed-effect-concentration(NOEC) burn in an incinerator approved foi pesticide destruc-
<br /> was 31 mg/cubic meter. tion. Do not reuse container.
<br /> CHRONIC TOXICITY: Dogs were administered 14. TRANSPORTATION INFORMATION:
<br /> metribuzin for 2 years at dietary concentrations of
<br /> 25, 100 and 1500 ppm. Effects observed at the TECHNICAL SHIPPING NAME:Metribuzin
<br /> high concentration included decreases in body weight FREIGHT CLASS PACKAGE: Herbicides, NOI -
<br /> and food consumption, anemia, liver effects, kidney NMFC 50320,Sub 2
<br /> effects, testicular effects and mortality. The NOEL PRODUCT LABEL:SENCOR DF
<br /> was 100 ppm. In chronic studies using rats,metribuzin DOT(DOMESTIC SURFACEI
<br /> was administered for 2 years at dietary concentrations HAZARD CLASS OR DIVISION:Non-Regulated
<br /> ranging from 25 to 900 ppm. At concentrations of 300 IMO/IMDG CODE OCEAN
<br /> ppm and greater,effects observed included decreased HAZARD CLASS DIVISION NUMBER: Non-
<br /> body weight gains, increased thyroid weights and Regulated
<br /> changes in thyroid hormones. At 900 ppm,there was ICAO/IATA(AIR)
<br /> w an increased incidence of follicular hyperplasia seen HAZARD CLASS DIVISION NUMBER: Non-
<br /> in the thyroid. The systemic NOEL was 30 ppm. Regulated
<br /> CARCINOGENICITY:Metribuzin was investigated for 15. REGULATORY INFORMATION:
<br /> carcinogenicity in chronic feeding studies using rats
<br /> and mice at maximum levels of 900 and 3200 ppm, OSHA STATUS:This product is hazardous under the
<br /> respectively.There was no evidence of a carcinogenic criteria of the Federal OSHA Hazard Communication
<br /> potential observed in either species. Standard 29 CFR 1910.1200.
<br /> MUTAGENICITY: Numerous in vitro and in viva TSCA STATUS: This product is exempt from TSCA
<br /> mutagenicity studies have been conducted with Regulation under FIFRA Section 3(2)(6)(ii)when used
<br /> metribuzin. The data,taken collectively,demonstrates as a pesticide. j
<br /> that metribuzin is not genotoxic CERCLA REPORTABLE QUANTITY:None
<br /> DEVELOPMENTAL TOXICITY: In a developmental SARA TITLE III:
<br /> toxicity study using rats,metribuzin was administered , SECTION 302 EXTREMELY HAZARDOUS SUB-
<br /> orally during gestation at doses of 25,70 or 200 mg/kg. STANCES:No components listed
<br /> Maternal toxic effects were observed at all doses. De- SECTION 311/312 HAZARD CATEGORIES:Immedi-
<br /> velopmental effects were observed at 200 mg/kg.The ate Health Hazard
<br /> s NOELS for material and developmental toxicity were SECTION 313 TOXIC CHEMICALS:Metribuzin(CAS
<br /> less than 25 mg/kg and 70 mg/kg,respectively.When No. 21087-634-9)-75
<br /> rabbits were administered metribuzin by oral gavage RCRA STATUS: If discarded in its purchased form,
<br /> during gestation at doses of 10,30 or 85 mg/kg,there this product would not be a hazardous waste either by
<br /> was no evidence of any developmental effects. The listing or by characteristic. However, under RCRA, it
<br /> NOELs for maternal and developmental toxicity were is the responsibility of the product user to determine at
<br /> r. 30 and 85 mg/kg,respectively. the time of disposal,whether a material containing the
<br /> REPRODUCTION:In a reproduction study using rats, product or derived from the product should be classified
<br /> metribuzin was administered for 2 generations at di- as a hazardous waste. (40 CFR 261.20-24) j
<br /> etary concentrations of 30,150 or 750 ppm. Offspring 16. OTHER INFORMATION:
<br /> at the high dose exhibited reduced body weight gains NFPA 704M RATINGS:
<br /> starting at Day-14 lactation,an age correlating with the
<br /> consumption of treated diets. The NOELS for mater- Health 1
<br /> nal and reproductive toxicity were 30 and 750 ppm, Flammability 3
<br /> respectively. Reactivity 1
<br /> NEUROTOXICITY: In an acute neurotoxicity screen- Other
<br /> ing study using rats,metribuzin technical was adminis- O=Insignificant 1=Slight 2=Moderate 3=High 4=Ex-
<br /> ow tered as a single oral dose at doses of 2,5,20or 100 treme I
<br /> mg/kg.Transient neurobehavioral effects were evident ; Bayer's method of hazard communication is comprised
<br /> in both sexes at dose levels of 5 mg/kg and greater. of Product Labels and Material Safety Data Sheets.
<br /> There were no treatment-related lesions within the NFPA ratings are provided by Bayer as a customer
<br /> skeletal muscle or neural tissues. Based on these re- : service.
<br /> suits,the NOEL for microscopic lesions for both sexes REASON FOR ISSUE: Revise address, telephone
<br /> is 100 mg/kg, the highest dose tested. The overall numbers,and new EPA Reg. No.
<br /> NOEL for both sexes from this study was 2 mg/kg PREPARED BY:T.M.Myers
<br /> based on transient neurobehavioral effects. In a 13- APPROVED BY: S.E.Earnest
<br /> week neurotoxicity screening study,metribuzin techni- TITLE:Manager,Quality System Services
<br /> cal was administered to rats at dietary concentrations APPROVAL DATE:03/03/2003
<br /> of 30, 300 or 900 ppm. Body weight and food con- SUPERSEDES DATE:05/10/2001
<br /> sumption was reduced for females at concentrations MSDS NUMBER:08438
<br /> of 300 or 900 ppm. Functional observational batttery This information is furnished without warranty, ex-
<br /> (FOB)and automated measures of motor and locomo- pressed or implied, except that it is accurate to the
<br /> for activity were not affected by treatment. There were best knowledge of Bayer CropScience. The data on
<br /> no treatment-related microscopic lesions in neural tis- this sheet relates only to the specific material desig-
<br /> sues or skeletal muscle in any of the treated animals. nated herein. Bayer CropScience assumes no legal
<br /> There was no evidence of neurotoxicty at any dietary. responsibility for use or reliance upon these data.
<br /> The NOEL for microscopic lesions was 900 ppm,the
<br /> highest concentration tested. The NOEL for overall Product Code: 14175 VID 5.8.03
<br /> r toxicity was 900 ppm for males and 300 ppm for fe-
<br /> males.
<br /> 12. ECOLOGICAL INFORMATION:
<br /> This product has been thoroughly evaluated for ecolog-
<br /> ical effects. Bayer will provide a summary of specific
<br /> data upon written request. As with any pesticide,this
<br /> product should be used according to label directions
<br /> and should be kept out of streams, lakes and other
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