|
Propylene glycol -Wikipedia, free encyclopedia Page 4 of 5
<br /> Allergic reaction
<br /> Research has suggested that individuals who cannot tolerate propylene glycol probably experience a
<br /> special form of irritation, but that they only rarely develop allergic contact dennatitis. Other
<br /> investigators believe that the incidence of allergic contact dermatitis to propylene glycol may be greater
<br /> than 2%in patients with eczema.('5]
<br /> Patients with vulvodynia and interstitial cystitis may be especially sensitive to propylene glycol. Women
<br /> struggling with yeast infections may also notice that some OTC creams can cause intense burning.
<br /> (16]Post menopausal women who require the use of an estrogen cream may notice that brand name
<br /> creams made with propylene glycol often create extre-nte, uncomfortable burning along the vulva and
<br /> perianal area. In these cases, patients can request that a local compounding pharmacy make a "propylene
<br /> glycol free" cream.
<br /> Possible air germicide
<br /> Studies conducted in 1942 by Dr. Oswald Hope Robertson of University of Chicago's Billings Hospital
<br /> showed vaporized propylene glycol inhalation in laboratory mice may prevent pneumonia, influenza,
<br /> and other respixltory diseases. Additional studies in monkeys and other animals were undertaken to
<br /> determine longterm effects, especially the potential for accumulation in the lungs,[17)
<br /> References
<br /> 1. ^Merck Index, I I th Edition,7868.
<br /> 2. ^ "1,2-Propanediol". Cheumindustry.ru-http://chem.industry.ru/1,2-Propanediot.php. Retrieved on 2007-12-
<br /> 28.
<br /> 3. ^ Chauvel,Alain;Lefebvre,Gilles.Petrochemical Processes(Volume 1:Spilhesis-Gas,Derivatives and
<br /> Major Hydrocarbons).Editions Teebuip.pp.26. ISBN 978-2-7108-0562-5.
<br /> 4. ^ 1,2-propanediol: chemical product info at CHEMINDUSTRY.RU
<br /> 5. ^ "Janusz Szajewski,MD ,Warsaw Poison Control Centre(August, 1991). "Propylene glycol (PIM 443)
<br /> IPCS INChem.http-//vww.inchein.org/documents/piens/cheinical/pim443.lirm.Retrieved on July 2,2009-
<br /> 6. ^http://pubs.acs.org/cen/wliatmf`f/stuff/7901scit5,htinl
<br /> 7. ^Gaunt,IF,Catpanini,FMB,Grasso,P and Lansdown,ABG,Long-term toxicity of propylene glycol in
<br /> rats,Food and Cosmetics Toxicology,Apr. 1972, 10(2),pages 151 - 162.
<br /> S. ^ National Library of Medicine;.Propylene glycol is used in antifreezes Hurnan Toxicity Excerpts: CAS
<br /> Registry Number: 57-55-6(1,2-Propylene Glycol).Selected toxicity information from HSDB. 2005.
<br /> 9. ^Flanagan RJ;Braitliwaite RA;Bmwn SS;Widdop B;de Wolff FA;,The International Programme on
<br /> Chemical Safety: Basic AAalytical Toxicology. WHO, 1995.
<br /> 10. ^ Peterson, Michael;Taleott,Patricia A. (2006). Small animal toxicoloD% St. Louis: Saunders Elsevier.
<br /> PP- 997- ISBN 0-7216-0639-3.
<br /> 11. ^ See 21 CFR 589.1001
<br /> 12. ^A Guide to Glycols
<br /> (http://www,dow.coin/PublishedLiteratuTe/dh 0047/090lb803800479d9.pdf#page=36),page 36-
<br /> 13 ^ 1,2-Dihydroxypropane SIDS Initial Assessment Profile
<br /> (http://www.chem.unep.el-/irpte/sids/OECDSIDS/57-55-6.pdf),UNE? Publications,SIAM 11, U.S.A,
<br /> January 23-26, 2001,page 21.
<br /> 14. ^ Title 21,U.S.Code of Federal Regulations. 1999.
<br /> 15. ^ American Medical Association,Council on Drugs(1994).AMA Drug Evaluettiuns Annual 1994(Chicago,
<br /> Illinois. American Medical Association): 1224.
<br /> 16. ^ Elizabeth Vliet MD, Screaming To Be Heard: Hormonal Connections That Women Suspect and Doctors
<br /> Ignore". M. Evans and Company,Inc.New York 1995
<br /> http://en.wikipedia.org/wiki/Propylene_glycol 8/7/2009
<br />
|