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SAFETY DATA SHEET <br /> AMMONIUM BIFLUORIDE <br /> Revision Date 12/19/2017 <br /> Mutagenicity <br /> Genotoxicity in vitro <br /> Ammonium fluoride ((NH4)(HF2)) Mutagenicity(Salmonella typhimurium-reverse mutation assay) <br /> with and without metabolic activation <br /> negative <br /> Method: OECD Test Guideline 471 <br /> Unpublished reports <br /> In vitro tests did not show mutagenic effects <br /> By analogy <br /> Gene mutation assays in mammalian cells. <br /> Strain: mouse lymphoma cells <br /> with and without metabolic activation <br /> positive <br /> Method: OECD Test Guideline 476 <br /> Published data <br /> In vitro tests showed mutagenic effects <br /> By analogy <br /> Chromosome aberration test in vitro <br /> Strain: CHO <br /> with and without metabolic activation <br /> ambiguous <br /> Method: OECD Test Guideline 473 <br /> Published data <br /> Genotoxicity in vivo <br /> Ammonium fluoride ((NH4)(HF2)) By analogy <br /> In vivo tests did not show mutagenic effects <br /> Carcinogenicity <br /> Ammonium fluoride ((NH4)(HF2)) By analogy <br /> No carcinogenic effects have been observed <br /> This product does not contain any ingredient designated as probable or suspected human carcinogens by: <br /> ACGIH <br /> Toxicity for reproduction and development <br /> Toxicity to reproduction/fertility <br /> Ammonium fluoride ((NH4)(HF2)) By analogy, No toxicity to reproduction <br /> Developmental Toxicity/Teratogenicity <br /> Ammonium fluoride ((NH4)(HF2)) By analogy, No embryotoxic effects have been observed in animal tests. <br /> P00000020030 <br /> Version : 1.04 / CA(Z8) <br /> SO LVAY <br /> www.solvay.com <br /> 11/18 <br />