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IMMON Unleaded Gasoline Page g of 10 monitoring, respiratory protection and medical surveillance triggered by .he exposure level. Refer to the OSHA Standard before using this product. 'lepeated or prolonged breathing of benzene• vapors has been a:;suciated with the development of chromosomal damage in experimental animals and various .olood diseases in humens rangino from aplastic anemia to leukemia (a form of cancer). All of these diseases cdr.be fatal No birth defects have peen shown to occur in pregnant laboratory animals expo._d to doses nc.t toxic to the mother. However, some evidence of fetal toxicity such as delayed physical development has been seen at such levels. The available information on the effects of benzene on human pregnancies is inadequate but it has been established that benzene can cross the human placenta. This product contains n-hexane. Prolonged or repeated skin contact or breathing of vapors may cause nerve damage characterized by }progressive weakness and numbness in the arms and legs. Recovery ranges from no recovery to complete recovery depending upon the severity of the nerve damage. 'Chis product contains toluene. Toluene has been reported to decrease immunological responses in test animals. It has also been reported that When young rats were exposed to 1000 ppm toluene for 14 hourz; daily, for two weeks, irreversible hearing loss was detected. The same da:ly exposure to 700 ppm for as long as 16 weeks was without effect. Since the level necessary to produce hearing loss is greater than. 7 times the 7987-88 ACGIli TLV for toluene, worker exposures at or below 100 ppm .s not expected to cause any adverse effect. There are also report:; that chronic abusers (glue sniffers, solvent huffers) of solvents contain .nc toluene have suffered liver, kidney and brain damage. Scientific st;idies on toluene have failed to demonstrate birth defects in rats and mice. However, toluene has been shown to cause delayed growth and extra ribs in the offspring of rats and mice at inhaled doses (266-399 ppm) that were non-toxic :o the mother. Toluene has not conclusively been shovit to cause adverse rearoductive effects in humans. -This product contains xylene, a chemical that has been reportee. to cause Aevelopmental toxicity in rats and mice exposed by inhalation curing !regnancy. The effects noted consisted of delayed development and minor skeletal variations; additionally, when pregnant mice were exposed by ingestion to a level that killed nearly one-third of the test croup, lethality (resorptions) and malformations (primarily cleft pali,te) occurred. Malformations have not been reported iollowing inhalation exposure. Because of the very high levels of exposure used in these studies, we do not believe that their results imply an increased risk of reproductive toxicity to workers exposed to xylene levels at ov below the exposurt• standard. Xylene Las given negative results in several mutagen testing assays including the Ames assay. In a cancer study sponsored by the National Toxicology Program (NTP) , technical grade xylene gave no evidence of carcinouenicity in rsts or mice dosed daily for two years. Whole Qilsoline exhaust was reviewed by the international Agency for Researc', on Cancer (IARC) in their Monograph Volume 46 (1969). Evidence for cau:;ing cancer was considered inadequate in animals and inadequate in )tev.ision Number: la Revision Rate: 03/24/90 KSDS Number: 000372 NDA - No Data Available NA - Not Applicable I