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Section 11. Toxicological information <br /> Information on toxicological effects <br /> Acute toxicity <br /> Product/ingredient name Result Species Dose Exposure <br /> Calcium Carbonate LD50 Oral Rat 6450 mg/kg - <br /> IrritatiorVCorrosion <br /> Product/ingredient name Result Species Score Exposure Observation <br /> Calcium Carbonate Eyes-Severe irritant Rabbit - 24 hours 750 - <br /> Micrograms <br /> Skin-Moderate irritant Rabbit - 24 hours 500 - <br /> milligrams <br /> Titanium Dioxide Skin-Mild irritant Human - 72 hours 300 - <br /> Micrograms <br /> Intermittent <br /> Tetremethyl Decynediol Eyes-Severe irritant Rabbit - 0.1 Mililiters - <br /> Skin-Mild irritant Rabbit - 0.5 Grams - <br /> Sensitization <br /> Not available. <br /> Mutagenicity <br /> Not available. <br /> Carcinogenicity <br /> Not available. <br /> Classification <br /> Product/ingredient name OSHA IARC NTP <br /> Crystalline Silica, respirable - 1 Known to be a human carcinogen. <br /> powder <br /> Titanium Dioxide - 2B - <br /> Reproductive toxicity <br /> Not available. <br /> TeratommiciN <br /> Not available. <br /> Specific target organ toxicity(single exposure) <br /> Not available. <br /> Specific target organ toxicity(repeated exposure) <br /> Name Category Routeof Target organs <br /> exposure <br /> Crystalline Silica, respirable powder Category 1Inhalation Not determined <br /> Mica Category 1 Inhalation lungs <br /> Aspiration hazard <br /> Not available. <br /> Date ofissumDate ofreWWw :9/9/2011 Dateofpreviousissue :4/18/2011 Version :8 6112 <br />