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• <br /> ET HYLBENZENE 01 02,10,1 1,14,15,17,18,26,28, <br /> P-XYLENE (I 4-DIMETHYL BENZENE) 01,02 10 11,26,28, <br /> M-XYLENE 01,02 10 11,14 15 17,18 26,28 <br /> TOLUENE O 1 02 10 11,14 15 17 18 26 28 <br /> HEXANE 02,10,1 l,14,17,28 <br /> CYCLOHEXANE 41,02,10,1 1,14 17 26,28 <br /> METHYL TERT BUTYL ETHER 01 10 112426 <br /> BENZENE O 1 02,03,04,06,10 11 14,17,18 20 28 <br /> 0-XYLFNE(1,2-DIMETHYL BENZENE) 01 02 10 11 14 15 17 18 26 28, <br /> GASOLINE(GENERIC) 04,48,14 15 17 IS 20 <br /> REGULATORY LISTS <br /> 01-SARA 313 02=MASS R1 K 03-NTP Carcinogen <br /> 04--CA Prop 65 05=M1406 06=IARC Group 1 <br /> 07=IARC Group 2A 08-IARC Group 213 09-SARA 302/304 <br /> 10=PA RTK 1 1-NJ RTK 12-CERCLA 302 4 <br /> 13=MN RTK 14=ACGIII TLV 15=ACGIH STEL <br /> 16=ACGIH Calculated TLV 17=0SHA PEL 18=0SHA STEL <br /> 19=Chevron TLV 20=FPA Carcinogen 21-TSCA SECT 4 <br /> 22-TSCA SECT 5 SNUR 23=TSCA SECT 6 RULE 24-TSCA SECT 12 EXPORT <br /> 25-TSCA SECT 8A CA1R 26-TSCA SECT 8D REPORT 27=TSCA SECT 8E <br /> 28-Canadian WHMIS <br /> 1 1 PRODUCT TOXICOLOGY DATA <br /> EYE IRRITATION <br /> The Draize Eye Irritation Score (range O-1 10) in rabbits is O <br /> SKIN IRRITATION <br /> The Dratze Skin Primary Irritation Score(range,0-8) for a 4-hour exposure(rabbits)is 0 98 This material was not a skin <br /> sensitizer in the modified Buehler Guinea Pig Sensitization Test <br /> DERMAL TOXICITY <br /> The dermal LD50 in rabbits is> 5 ml/kg <br /> RESPIRATORY/INHALATION NDA <br /> INGESTION The oral LD50 in rats if> 5 ml/kg <br /> ADDITIONAL TOXICOLOGY DATA <br /> Lifetime inhalation of whole gasoline vapor has caused increased liver tumors in female mice The mechanism of this <br /> response is stili being investigated but it is thought to be an epigenetic process unique to the female mouse Inhalation <br /> exposure to whale gasoline vapor also caused kfdney damage and eventually kidney cancer in male rats <br /> No other animal model sludvcd has shown ih(-scadv,-rse kidney effects and there is no physiological reason to believe that <br /> they would occur in man The cause of the kidncy toxicity ib thought to be due to the interaction of isoparaffin <br /> hydrocarbons in the product with a specific serum protein alpha-2-microglobulin Male rats synthesis large amounts of <br /> this protein which is filtered, reabsorbed and degraded by their kidneys Isoparafiins or their metabolites combine with <br /> this protein and make it"undigestable"by the kidney proteases With repeated exposure,the protein-isoparaf in complex <br /> accumulates in the kidney tubules causing significant cell death and regrowth It is thought that this continuous kidney <br /> Injury may contribute to the eventual development of the tumors <br /> The data above is obtained from studies sponsore-KI by the American Petroleum Institute(API) <br /> Material Safety Data Sheet - Chevron Unleaded Gasoline page 6 <br />