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' No 318 Xylene(,Laxed Isomers) 9192
<br /> Section 6 Health Hazard Data continued
<br /> u-regularmty was reported u1 assoetation With workplace exposure to xylene perhaps due to effects on liver mctabollsm Xylene crosses the human
<br /> placenta, but docs not appear to be terato onto under conditions tested to date MedlcW Conditions Aggravated by Long 'Term Exposure CNS
<br /> respiratory,eye,skin gastrointestinal(G� liver and kidney disorders Target Organs CNS eyes,G!tract,lever,kidneys,and skirl Primary
<br /> Entry Routes Inhalation,sk-m absorption(sight),eye contact,ingestion Acute Effects inhalation of high xylene concentrations may cause
<br /> iness, nausea vomuting and abdominal pain eye,nose,and dlsoet irritation,rt spiratory tract rrnu ition leading to pulmonary edema(fluid in
<br /> g) drowsiness and unconsciousness Direct eye contact can result in conlunctivius and coaxal burns Ingestion may cause a burning sensation
<br /> n the oropharynx and stomach and transient CNS depression Chrook-Effects Repeated or prolonged skin contact may cause drying and defat-
<br /> ung of the stun leading to dermatitis Repeated eye exposure to high vapor concentrations may cause reversible eye damage,peripheral and central
<br /> neuropathy and liver damage Other symptoms of chronic exposure include headache,fatigue,irritability,chronic broncluus,and I dLsturbances
<br /> such as nausea,lou of appetite,and as
<br /> FIRST AID Ernergenty personnel should protect agatnrt exposure Eyes Do not allow victim to rub or keep eyes tightly shut.Gently left eyebds
<br />' and flush irnmednatel and continuously with flooding amounts of water until transported medical facility Consult a phystcian
<br /> d to an emergency
<br /> immediately Sk Inuntkly remove contarrunated clothing Russe with flooding amounts of water for at lust l5 run Wash exposed area wnrh soap
<br /> and water For reddened or blistered skin consult a physician Carefully dispose of contaminated clothing as it may pose a due hazard lnhalatlott
<br /> Remove exposed person to fresh air and support breathing as needed Monitor exposed person for respiratory distress Ingestion Plover give
<br /> anything by moth to an unconscious or convulsing person Contact a poison control center and unless otherwise advised,do not tnd=e vomitingr If
<br /> spontaneous vomiting should occur,keep exposed persons head below the hips to prevent aspiration(breathing liquid xylene into the lungs)
<br /> Aspiration of a fewmilhmeters ofitylerte can cause chenucal pnewrwnrto pulmonary edema,and hemorrhage Note to Physicians Hnppunc and
<br /> or the ether glucuronide of ortho-toluic acid may be useful in diagnosis of meta ,para- and ortho-xylene exposure,respectively Cons"d gastric
<br /> lavage if a large quantity of xylene was ingested Proceed gastric lavage with protection of the airway from aspiration,consider endotracheal
<br /> intubation with inflated cuff
<br /> Section 7. Spill, Leak, and Disposal Procedures
<br /> SpilI/Leak Notify safety personnel,evacuate&11 unnecessary peisonneL remove all heat and ignition sources,and ventilate spill arca.Cleanup
<br /> personnel should protect against vapor inhalation and skin or eye contact.U feasible and without undue nsk,stop leap-Use appropriate foam to
<br /> blanket release and suppress vapors Water spray may reduce vapor,but does not prevent ignition in closed spaces For small spills,absorb on paper
<br /> and evaporate in appropriate exhaust hood or absorb with sand or some non-combustible absorbent and place in containers for later disposal For
<br /> large spills dike far ahead of liquid to contain Do not allow xylene to enter a confuted space such as sewers or drains On land,dike to contain or
<br /> divert to impermeable holding area Apply water spray to control flammable vapor and remove material with pumps or vacuum equipment On
<br /> water,contain rriatenal with natural barriers,booms or weirs,apply universal gelling agent,and use suction hoses to remove spilled material
<br /> Report any release in excess of 1000 lb Follow applicable OSHA regulations(29 CFR 1910 120) Environmental Transport -role bioconcen-
<br /> tration is expected Biological oxygen demand 5(after 5 days at 20'C) 0 64(no stated isomer) Ecotoxkity values LDS Goldfish. 13 m*/L/24 hr,
<br /> conditions of bioassay not specified,no specific isomer £nvdronmenW Degradation In the atmosphere,xylenes degrade by reacting with
<br /> photochemically produced hydroxyl radicals with a half-life ranging from 1-17 hr in the summer to 10-18 hr in winter or a typical lass of 67-86%
<br /> per day Xylenes are resistant to hydrolysis Sofl Absorptlon/MobIlity Xylenes have low to moderate adsorption to soil and when spilled on land,
<br /> will volatilize and leach into groundwater Disposal As a hydrocarbon,x lone u a good candidate for controlled incineration-Contact your supplier
<br /> or a licensed contractor for detailed recommendations Follow applicable Federal,state,and local regulations
<br /> PA Designations OSHA Deslgnations
<br /> RA Extremely Hazardous Substance(40 CFR 355) Not listed lusted as an Air Contaminant(29 CFR 1910 1000,Table Z-1-A)
<br /> isted as a SARA Toxic Chemical(40 CFR 372 65)
<br /> Listed as a RCRA Hazardous Waste(40 CFR 26133) No U239,F003(spent solvent)
<br /> Lasted as a CERCLA Hazardous Substance* (40 CFR 302 4) Final Reportable Quantity(RQ),1000 lb(454 kg)("per Clean Water Act,
<br /> Sec 311(b)(4),per RCRA,Sec 3001]
<br /> Section 8. Special Protection Data
<br /> Goggles Wear protective eyeglasses or chemical safety goggles,per OSHA eye-and face-protection regulations(29 CFR 1910 133) Because
<br /> contact lens use in industry is controvastal.establish your own policy Rc p",or,Seek professional advice prior to respirator selection and use
<br />' Follow OSHA respirator regulations(29 CFR 1910 134)and,if necessary,wear a MSHA JOSH-approved respirator For concentrations>1000
<br /> ppm,use any chemical cartridge respirator with organic vapor cartridges,any powered,az-punfyung resptrator with or�arnic vapor cartridges,any
<br /> supplied-au respirator,,or any self-contained breathumg apparatus For emergency or nonroutine operations(cleaning spills,reactor vessels.or
<br /> storage tanks),wear an SCBA Warnings Air-purifying respirators do not protect workers in oxygen-defrcrent atmospheres lfmlimtors are used.
<br /> Other Wear chemically protective gloves,boots.aprons and gauntlets to prevent all skin contact With breakthrough tunes>8 hr.consider
<br /> polyvinyl alcohol and fluorocarbon rubber(Viton)as materials for PPE-Ventilation Provide general and local exhaust venu3ation systems to
<br /> maintain airborne concentrations below the OSHA PELs(Sec 2) Local exhaust ventilation is preferred because it prevents Gontamtnant dispersion
<br /> into the work area by controlling it at its source tusk Safety Stations Make available in the work area emergency eyewash stations,safety/quick-
<br /> drench showers,and washing facilities Contaminated Equipment-Separate contaminated work clothes from street clothes Launder contami-
<br /> nated work clothing before wearing Remove this material from your shoes and clean PPE Continents Never cat,dnnk,or smoke in wane areas
<br /> Practice good pexsonaf hygiene after using thLs maternal,especially before eating.dnriking,smoking.using the toilet,or applying cosmetics
<br /> Section 9. Special Precautions and Comments
<br /> Storage Requirements Store in clearly labelled,tightly closed,containers Ina cool,well-ventilated plaice,away from strong oxidmng materials
<br /> and heat and ignition sources Dunng transferring operations,electrically ground and bond metal containers Engineering Controls.To reduce
<br /> potential health hazards,use sufficient dilution or local exhaust ventilation to control airbo me contaminants and to maintain concentrations at the
<br /> lowest practical level Use hermetically sealed equipment,transfer xylene in enclosed systems,avoid processes associated with open evaporating
<br /> surfaces,and provide sources of gas release:with enclosures and local exhaust ventilation Use Class t Group D electrical equipnxal-Admintstra-
<br /> live Controls Establish au and biological monitoring programs and evaluate reggularly Consider preplacement and periodic medical examuutions
<br /> including a complete blood count,a routine unnalysu,and liver function tests Consida hematologic studies if there is any significant contamination
<br /> of the solvent with benzene If feasible,consider the replacement of xylene by less toxic solvents such as petrol(motor fuel)or white spent.Before
<br /> carrying out maintenance and repair work steam and flush all equipment to remove any xylene residues
<br /> Transportation Data(49 CFR 172.101)
<br /> (MSD
<br /> pping\amt Xylenes Packagln2 Authorizations Quantity Limitations Vessel Stowage Reqquirements
<br /> ard Class 3 a) Exceptions 173 150 a) Passcnger,Aircraft,or Railcar 5L a)Vessel Stowage B
<br /> N
<br /> N 1307 b)Nonbuilc Packaging 173 202 b)�8o Aircraft Only 60L b)Oilier—
<br /> king Group II t) Bulk Packaging 173 242
<br /> el Flammable Liquid
<br /> rovisions(172 102) Tl
<br /> llrcuon References 26,73,89 100 101 1113,124, 126 127,132 133 136,139, 140, 148, 149, 153, 111 163,154,167,171,174 176,180by MJ Wunh 85 Industrial Hygiene Review PA Roy,MPH CU-1 Medical Review W Silverman,MD
<br /> Copyrq)%o 1992 by Corwin Pu bluhms Corps.t,ea Amy cvrvt>ect•1,r=a npeadw L� .aSwt the pobr t.hm i prsm+r coo■prow 1r,dpnem u w the n tuN try or mtorm+t,ae Uce res
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