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YS <br /> nzene <br /> OS-1121 <br /> Page 3 <br /> SECTION IV. LANG-TERM ORGANISM THREAT POTENTIAL <br /> Carcinogenicity <br /> IAR : Limited evidence of carcinogenic effects in animals . Sufficient <br /> evidence of carcinogenic effects in humans. <br /> NTP/NCI: NT?/NCI has reported carcinogenic effects . <br /> G has reported carcinogenic effects. <br /> SCS: Carcinogenic by RTECs criteria based on cases of leukemia in <br /> Wu—mans and rats. Carcinogenic by RTECS criteria in mice. <br /> Mutagenicity <br /> MC: Not mutagenic in bacteria, yeast, 'insects , or mouse lymphoma <br /> cells. Chromosomal anomalies in humans, rats , and mice were observed. <br /> RTECS: Positive mutagenic responses in bacteria, mice, rats , and <br /> ran its were observed. DNA damage and chromosomal breaks in humans <br /> were observed. <br /> Teratogenicity <br /> AR : lail abnormalities, cleft palate, and absence of the lower jaw <br /> were defects observed in mice. Brain and skeletal defects in rats were <br /> observed. Other studies did not show teratogenic effects . <br /> RTECS: Abnormalities of the musculoskeletal system and other effects <br /> on the newborn were observed in rats and mice. <br /> Reproductive Effects ' <br /> !A. Etera ion of estrus cycles in rats was observed. Increased <br /> testicular .veight and degeneration of the seminiferous tubules in rats , <br /> guinea pigs , and rabbits were observed. Fetotoxicity in rats and mice <br /> were observed. <br /> RTECS: Fetotoxicity, post-implantation mortality, and extra embryonic <br /> structures in rats and ;nice were observed. Pre-implantation mortality, <br /> fetal death, and other fetal effects in mice were observed. <br /> SECTION V. CHRONIC TOXICITY <br /> Appetite joss , weign4 loss , fatigue, muscle weakness , headaches, <br /> dizziness , nervousness , irritability, anemia, irreversible blood changes, <br /> and damage to the heart and l iver. <br /> SECTION VI. PHYSICAL DATA <br /> Molecular wei ht: 78.12 <br /> Boo Tn : oin: at 760 mm Ho) : 80*C (170:F) . <br /> Me . tin , oin;. at a rnm Pfd ) : 5 .5*C (42 F) <br /> Vapor Pressure (mm Ho) -gat 20 C (58*F)] : 74.6 <br /> Vapor Density Air. ) : . <br /> Saeci is Gravity (water-l ) : 0.879 <br /> Percent Volatile By + o ume: 100 <br /> vaooration Rate (outyl acetate =1 ) : I <br /> So ,uoiity to Water: Soluole <br /> s;fent So IUDI I Ity: Miscible with alcohol , chloroform, ether, carbon <br /> u,sutride, caroon tetrachloride, lacial acetic acid, acetone, oils . <br /> Anoaarance and odor: Clear , col or l ess , fl a=ab le liquid with an odor <br /> j rrresno a or a ppm. <br /> I <br /> ENViR01OC�ic BATA <br />