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Benzene <br /> MSOS-1121 <br /> Page 3 <br /> SECTION IV. LONG-TERM ORGANISM THREAT POTENTIAL <br /> Carcinogenicity <br /> !ARC: Limited evidence of carcinogenic effects in animals . Sufficient <br /> evidence of carcinogenic effects in humans . <br /> NTP/NCI: NTP/NCI has reported carcinogenic effects . <br /> CAG: C G has reported carcinogenic effects. <br /> `77C S: Carcinogenic by RTECs criteria based on cases of leukemia in <br /> humans and rats. Carcinogenic by RTE-,-.s criteria in mice. <br /> Mutagenicity <br /> 1AR : .Not mutagenic in bacteria, yeast, insects , or mouse lymphoma <br /> ce Ts. Chromosomal anomalies in humans , rats , and mice were observed. <br /> RTECS: Positive mutagenic responses in bacteria, mice, rats , and <br /> raooits were observed. DNA damage and chromosomal breaks in humans <br /> were observed. <br /> Teratogenicity <br /> 1AR : Fail abnormalities, cleat palate, and absence of the lower jaw <br /> were defects observed in mice. 3rain and skeletal defects in rats were <br /> observed. Other studies did not show teratogenic effects . <br /> RTECS: Abnormalities of the musculoskeletal system and other effects <br /> on the newborn were observed in rats and mice. <br /> Reproductive Effects <br /> FAR : Alteration of estrus cycles in rats was observed. increased <br /> testicular r4eight and degeneration of the seminiferous tubules in rats , <br /> guinea pigs , and rabbits were observed. Fetotoxicity in rats and mice <br /> were observed. <br /> RTECS: Fetotoxicity, post-implantation mortality, and extra embryonic <br /> s;.ructures in rats and Anice were ooserved. Pre-implantation mortality, <br /> fetal death, and other fetal effects in mice were observed. <br /> SECTION V. CHRONIC TOXICITY <br /> Appetite loss , weignt loss , faticue, muscle weakness , headaches , <br /> dizziness , nervousness , irritability, anemia, irreversible blood changes, <br /> and damage to the heart and liver. <br /> SECTION VI. PHYSICAL DATA <br /> Molecular weight: 78.12 <br /> Boll ing Point (at 760 mm Ha) : 80°C (176°F) <br /> Me , tina joint (at io mm Ha): 6 .5°C (42°F) <br /> Vapor Pressure (mm Ha) Lac 0°C (68°F)1: 74.6 <br /> Vapor Density ;fir=i) : <br /> Soecific Gravity (water=l): 0.379 <br /> Percent Vo ati e 3y olume: 100 <br /> vaooration Rate utyl acetate =1): 1 <br /> So uo i i ty in ',Dater: o f u❑ e <br /> ScTvent So u77Jty: Miscible with alcohol , chloroform, ether , carbon <br /> suirioe, caroon tetrachloride, glacial acetic acid, acetone, oils . <br /> Aopaarance and Odor: Clear, colorless , flammable liquid with an odor <br /> thresnoFa or a ppm. <br /> 1:NVIRO1OC, is BATA <br />