Laserfiche WebLink
SAFETY DATA SHEET ISSUED: 8/21/2018 <br /> REFERENCE: WH11-TO09 <br /> Specific target organ toxicity - single No data available <br /> exposure <br /> Specific target organ toxicity - repeated No data available <br /> exposure <br /> Aspiration hazard No data available <br /> TitaniumDioxide 13463-67-7 <br /> Acute toxicity - LD50 - oral - rat > 10000 mg/kg <br /> Acute toxicity - inhalation No data available <br /> Acute toxicity - LD50 - dermal - rabbit > 10000 mg/kg <br /> Skin irritation - human Mild skin irritation - 3 h <br /> Eye irritation - rabbit No eye irritation <br /> Respiration or skin sensitisation Will not occur <br /> Germ cell mutagenicity - hamster- ovary - No results available <br /> micronucleus test <br /> Germ cell muta enicit - hamster- lungs DNA inhibition <br /> Germ cell mutagenicity - hamster - ovary - No results available <br /> sister chromatid exchange <br /> Germ cell mutagenicity - mouse - No results available <br /> micronucleus test <br /> IARC No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a probable, possible or confirmed human carcinogen <br /> b IARC <br /> NTP No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a known or anticipated carcinogen <br /> OSHA No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a carcinogen or potential carcinogen by OSHA <br /> Reproductive toxicity No data available <br /> Specific target organ toxicity - single No data available <br /> exposure <br /> Specific target organ toxicity - repeated No data available <br /> exposure <br /> Aspiration hazard No data available <br /> Additional information To the best of our knowledge, the chemical, physical, and toxicological <br /> ro erties have not been thoroughly investigated <br /> Tris 2 4-ditert-but I hen I hos hite'31570-04-4 <br /> LD50 - oral - male and female rat -Acute > 6000 mg/kg <br /> Toxicity <br /> LD50 - dermal - male and female rat > 2000 mg/kg <br /> Skin irritation - rabbit No skin irritation/24 h <br /> Eye irritation- rabbit No eye irritation/ 30 s <br /> Respiratory or skin sensitization - guinea Does not cause skin sensitization <br /> i <br /> Germ cell mutagenicity -Ames test Negative <br /> (micronucleus test) - male and femae <br /> hamster <br /> Carcinogenicity - oral - male and female No adverse effect has been observed in chronic toxicity tests <br /> rat <br /> IARC No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a probable, possible, or confirmed human carcinogen <br /> by IARC <br /> ACGIH No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a carcinogen or potential carcinogen by ACGIH <br /> NTP No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a known or anticipated carcinogen <br /> OSHA No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a carcinogen or potential carcono en by OSHA <br /> Reproductive toxicity Not data available <br /> Developmental toxicity - oral - rabbit No adverse effect has been observed in chronic toxicity tests <br /> Specific target organ toxicity - single No data available <br /> exposure <br /> Specific target organ toxicity - repeated No data available <br /> exposure <br /> Additional information Repeated dose toxicity - rat- male and female - oral - No observed <br /> adverse effect level - >/ 1000 mg/kg <br /> Additional information No adverse effect has been observed in chronic toxicity tests <br /> Page 6 of 12 <br />