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8/21/2018 CARDINAL SAFETY DATA SHEET =RENEE: WH08-T0O00 REFERENCE: W H08- 2 Additional information Repeated dose toxicity - male and female rat- lowest observed adverse effect level - 2500 mg/kg Additional information To the best of our knowledge, the chemical, physical,and toxicological properties have not been thoroughly investigated Amorphous Silica(112926-00-8) Acute toxicity no data available Acute toxicity: Inhalation no data available Acute toxicity: Dermal no data available Skin irritation no data available Eye irritation no data available Respiratory or skin sensation no data available Germ cell mutagenicity no data available Carcinogenicity: IARC: Group 3: not cassifiable as to its carcinogenicity to humans ACGIH no component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by ACGIH NTP no component of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP OSHA no component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by OSHA Reproductive toxicity no data available Specific target organ toxicity -single no data available exposure Specific target organ toxicity -repeated no data available exposure Aspiration hazard no data available Additional information Amorphous silica is not classified as to its carcinogenicity to humans, however, crystalline silica inhaled in the form of quartz or cristobalite from occupational sources is carcinogenic to humans (Group 1,IARC). Therefore,amorphous silica should be handled as if possessing the same hazards as the crystalline form.To the best of our knowledge,the chemical, physical, and toxicological properties have not been thoroughly investigated. Additional information I Stomach -irregularities -based on human evidence Crystalline Silica(14808-60-7) Acute Inhalation toxicity no data available Acute Dermal toxicity no data available Skin irritation no data available eye irritation no data available Respiratory or skin sensation no data available Germ cell mutagenicity no data available Carcinogenicity Limited evidence of carcinogenicity in human studies IARC Group 1: Carcinogenic to humans (Quartz) E ACGIH No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by ACGIH NTP Known to be human carcinogen (Quartz) OSHA No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by OSHA Reproductive toxicity no data available Specific target organ toxicity -single no data available I exposure Specific target organ toxicity - repeated may cause damage to organs through prolonged or repeated exposure exposure - inhalation Aspiration hazard no data available Additional information Prolonged inhalation of crystalline silica may result in silicosis, a disabling pulmonary fibrosis characterized by fibrotic changes and miliary nodules in the lungs,a dry cough, shortness of breath,emphysema, decreased chest expansion,and increased susceptibility to tuberculosis. In advanced stage, loss of appetite, pleuric pain,and total incapacity to work. Advanced silicosis may result in death due to cardiac failure or destruction of lung tissue. Crystalline silica is classified as group 1 "known to be carcinogenic to humans" by IARC and "sufficient evidence"of carcinogenicity by the NTP., The chronic health risks are associated with respirable particles of 3-4 um over protracted periods of time. Currently, there is a limited understanding of the mechanisms of quartz toxicity, including its mechanisms for lung carcinogenicity.Additional studies are needed to determine whether the cell transforming activity of quartz is related to its carcinogenic potential. E Page 5 of 13 i