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ISSUED: 8/21/2018 <br /> CARDINAL SAFETY DATA SHEET <br /> REFERENCE: W H08-T002 <br /> 1004 <br /> Acute toxicity- inhalation No data available <br /> Acute toxicity- LD50 -dermal- rabbit > 10000 mg/kg <br /> Skin irritation -human Mild skin irritation- 3 h <br /> Eye irritation - rabbit No eye irritation <br /> Respiration or skin sensitisation Will not occur <br /> Germ cell mutagenicity -hamster- ovary - No results available <br /> micronucleus test <br /> Germ cell mutagenicity -hamster- lungs DNA inhibition <br /> Germ cell mutagenicity -hamster- ovary - No results available <br /> sister chromatid exchange <br /> Germ cell mutagenicity -mouse - No results available <br /> micronucleus test <br /> IARC No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a probable,possible or confirmed human carcinogen <br /> by IARC <br /> NTP No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a known or anticipated carcinogen <br /> OSHA No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a carcinogen or potential carcinogen by OSHA <br /> Reproductive toxicity No data available <br /> Specific target organ toxicity -single No data available <br /> exposure <br /> Specific target organ toxicity - repeated No data available <br /> exposure <br /> Aspiration hazard No data available <br /> Additional information To the best of our knowledge, the chemical, physical,and toxicological <br /> properties have not been thoroughly investigated <br /> Tris(2,4-ditert-butylphenyl)phosphite(31570-04-4) <br /> LD50- oral -male and female rat -Acute > 6000 mg/kg <br /> Toxicity <br /> LD50- dermal - male and female rat > 2000 mg/kg <br /> Skin irritation -rabbit No skin irritation / 24 h <br /> Eye irritation-rabbit No eye irritation/30 s <br /> Respiratory or skin sensitization -guinea Does not cause skin sensitization <br /> pig <br /> Germ cell mutagenicity -Ames test Negative <br /> (micronucleus test) -male and femae <br /> hamster <br /> Carcinogenicity - oral -male and female No adverse effect has been observed in chronic toxicity tests <br /> rat <br /> IARC No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a probable, possible, or confirmed human carcinogen <br /> by IARC <br /> ACGIH No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a carcinogen or potential carcinogen by ACGIH <br /> I NTP No component of this product present at levels greater than or equal to <br /> I 0.1% is identified as a known or anticipated carcinogen <br /> OSHA No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a carcinogen or potential carconogen by OSHA <br /> Reproductive toxicity Not data available <br /> i Developmental toxicity -oral- rabbit No adverse effect has been observed in chronic toxicity tests <br /> i Specific target organ toxicity -single No data available <br /> exposure <br /> Specific targetorgan toxicity -repeated No data available <br /> exposure <br /> Additional information Repeated dose toxicity - rat-male and female -oral - No observed <br /> adverse effect level - >/ 1000 mg/kg <br /> Additional information No adverse effect has been observed in chronic toxicity tests <br /> I <br /> Page 7 of 13 <br /> i <br />