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SAFETY DATA SHEET BK05- <br /> ISSUED: 8/22/2018 <br /> ...4CARDINAL <br /> REFERENCE: K05-TO06 <br /> 11.TOXICOLOGICALINFORMATION <br /> 1,3,5-TriI cid l Isoc anurate 2451-62-9 <br /> Acute toxicity - LD50 -oral - rat 100 - 200 mg/kg <br /> Acute toxicity - LC50 - inhalation - rat- > 650 mg/m3 <br /> male -4 h <br /> Acute toxicity - LD50 - Dermal - rat- male > 2000 mg/kg <br /> &female <br /> Skin irritation - rabbit Mild skin irritation - 24 hours <br /> Eye irritation - rabbit Severe eye irritation <br /> Respiratory or skin sensation - May cause sensitization by skin contact <br /> Maximization test- guinea pig <br /> Germ cell mutagenicity In vivo tests showed mutagenic effects <br /> Germ cell mutagenicity -AMES test- S. Positive <br /> typhimurium <br /> Germ cell mutagenicity -AMES test- Positive <br /> mouse - male <br /> IARC No component of this product present at levels greater than or equal to <br /> 0.1%is identified as a probable, possible or confirmed human carcinogen <br /> by IARC <br /> ACGIH No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a carcinogen or potential carcinogen by ACGIH <br /> NTP No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a known or anticipated carcinogen by NTP <br /> OSHA No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a carcinogen or potential carcinogen by OSHA <br /> Reproductive toxicity No data available <br /> Specific target organ toxicity -single No data available <br /> exposure <br /> Specific target organ toxicity - repeated No data available <br /> exposure <br /> Aspiration hazard No data available <br /> Additional information To the best of our knowledge, the chemical, physical, and toxicological <br /> properties have not been thoroughly investigated <br /> Amorphous Silica 112926-00-8 <br /> Acute toxicity no data available <br /> Acute toxicity: Inhalation no data available <br /> Acute toxicity: Dermal no data available <br /> Skin irritation no data available <br /> Eye irritation no data available <br /> Respiratory or skin sensation no data available <br /> Germ cell mutagenicity no data available <br /> Carcinogenicity: IARC: Group 3: not classifiable as to its carcinogenicity to humans <br /> ACGIH no component of this product present at levels greater than or equal to <br /> 0.1% is identified as a carcinogen or potential carcinogen by ACGIH <br /> NTP no component of this product present at levels greater than or equal to <br /> 0.1% is identified as a known or anticipated carcinogen by NTP <br /> OSHA no component of this product present at levels greater than or equal to <br /> 0.1% is identified as a carcinogen or potential carcinogen by OSHA <br /> Reproductive toxicity no data available <br /> Specific target organ toxicity -single no data available <br /> exposure <br /> Specific target organ toxicity - repeated no data available <br /> exposure <br /> Aspiration hazard no data available <br /> Additional information Amorphous silica is not classified as to its carcinogenicity to humans, <br /> however, crystalline silica inhaled in the form of quartz or cristobalite from <br /> occupational sources is carcinogenic to humans (Group 1, IARC). <br /> Therefore, amorphous silica should be handled as if possessing the same <br /> hazards as the crystalline form. To the best of our knowledge, the <br /> chemical, physical, and toxicological properties have not been thoroughly <br /> investigated. <br /> Additional information Stomach - irregularities - based on human evidence <br /> Barium Sulfate 7727-43-7 <br /> Acute toxicity - inhalation No data available <br /> Page 4 of 12 <br /> E <br />