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CARDINALL SAFETY DATA SHEET ISSUED: 8/22/2 <br /> REFERENCE: BK05-TO0 006 <br /> OSHA No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a carcinogen or potential carcinogen by OSHA <br /> Reproductive toxicity no data available <br /> Specific target organ toxicity - single no data available <br /> exposure <br /> Specific target organ toxicity - repeated may cause damage to organs through prolonged or repeated exposure <br /> exposure - inhalation <br /> Aspiration hazard no data available <br /> Additional information Prolonged inhalation of crystalline silica may result in silicosis, a disabling <br /> pulmonary fibrosis characterized by fibrotic changes and miliary nodules <br /> in the lungs, a dry cough, shortness of breath, emphysema, decreased <br /> chest expansion, and increased susceptibility to tuberculosis. In advanced <br /> stage, loss of appetite, pleuric pain, and total incapacity to work. <br /> Advanced silicosis may result in death due to cardiac failure or destruction <br /> of lung tissue. Crystalline silica is classified as group 1 "known to be <br /> carcinogenic to humans" by IARC and "sufficient evidence" of <br /> carcinogenicity by the NTP.,The chronic health risks are associated with <br /> respirable particles of 3-4 um over protracted periods of time. Currently, <br /> there is a limited understanding of the mechanisms of quartz toxicity, <br /> including its mechanisms for lung carcinogenicity. Additional studies are <br /> needed to determine whether the cell transforming activity of quartz is <br /> related to its carcinogenic potential. <br /> Additional information Liver- Irregularities - based on human evidence <br /> Limestone 1317-65-3 <br /> Draize test rabbit eye 750 u /24H severe <br /> Draize test rabbit skin 500 mg/24H moderate <br /> Oral rat: LD50 6450 mg/kg <br /> ACGIH IARC NTP CA Prop 65 Not listed <br /> Epidemiology No information available <br /> Teratogenicity No information available <br /> Reproductive effects No information available <br /> Mutagenicity No information available <br /> Neurotoxicity No information available <br /> Pentaerythritol tetra kis 6683-19-8 <br /> Acute toxicity - LD50 -oral - male rat > 5000 mg/kg <br /> Acute toxicity- LC50 - inahalation - male > 1.95 mg/I/4h <br /> and female rat <br /> Acute toxicity - LD50 - dermal - male and > 3160 mg/kg <br /> female rabbit <br /> Acute toxicity- LD50 - intraperitoneal - rat > 1000 mg/kg <br /> Skin corrosion - rabbit No skin irritation - 24 h <br /> Eye irritation - rabbit No eye irritation <br /> Respiratory or skin sesnsitization - guinea Does not cause skin sensitization <br /> i <br /> Germ cell mutagenicity -Ames test - S. Negative <br /> typhimurium <br /> Mutagenicity - micronucleus test- male Negative <br /> and female hamster <br /> IARC carcinogenicity No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a probable, possible, or confirmed human carcinogen <br /> b IARC <br /> ACGIH No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a carcinogen or potential carcinogen by ACGIH <br /> NTP No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a known or anticipated carcinogen by NTP <br /> OSHA No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a carcinogen or potential carcinogen by OSHA <br /> Reproductive toxicity No data available <br /> Specific target organ toxicity - single No data available <br /> exposure <br /> Specific target organ toxicity - repeated No data available <br /> exposure <br /> Aspiration hazard No data available <br /> Tris 2 4-ditert-but I hen I hos hite 31570-04-4 <br /> LD50 - oral - male and female rat -Acute > 6000 mg/kg <br /> Toxicity <br /> LD50 - dermal - male and female rat > 2000 mg/kg <br /> I <br /> Page 6 of 12 <br />