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285-21 2.1 VOC Primer NLR 285212 Page 4 SECTION 5 - HEALTH EFFECTS (cont) tract, breathing difficulties, coughing, CNS effects, pneumonitis and pulmonary edema. Inhalation of high acute concentrations of kaolin dust may produce physical irritation. Chronic inhalation of kaolin dust may produce respiratory symptoms and may also have a fibrogenic potential. Inhalation of Parachlorobenzotriflouride may produce symptoms of CNS depression including headache, dizziness, nausea, loss of balance and drowsiness. Ingestion may cause damage to the lining of the G.I. tract. Acute exposures to high concentrations of talc may produce cough, dyspnea, chest pain and weakness. Inhalation of 2-heptanone (methyl amyl ketone) may lead to upper respiratory tract irritation and central nervous system effects like headache, nausea and dizziness. Chronic Overexposure Effects: The primary route of entry when using paint or paint related products is considered to be inhalation. Some reports have associated repeated, prolonged overexposure to solvents with permanent central nervous system changes. Misuse by concentrating and inhaling the contents may be harmful or fatal. High doses of acetone (500 and 2500 mg/kg/day) administered by oral gavage to rats for 90 consecutive days resulted in some clinical chemistry and blood changes as well as increased absolute/relative liver and kidney weights. Histopathological examination of both organs showed acetone did not affect the liver but appeared to accentuate the kidney changes which accompany aging. No effects were observed at 100 mg/kg/day. Chronic occupational exposures to acetone at levels ranging from 300 to 100 ppm have reportedly been associated with irritation and mild CNS effects but have not affected clinical chemistry parameters or worker mortality. Chronic inhalation of barium compounds may result in condition known as baritosis, however, pe-rsons showing signs of this condition exhibit normal lung function. In teratology studies, pregnant rats exposed by inhalation exhibited slight fetotoxicity at the maternally toxic concentration of 1000 ppm• The International Agency for Research on Cancer (IARC) has classified formaldehyde as a Group 1 (known) human carcinogen based on epidemiological evidence linking formaldehyede exposure to occurence of nasopharyngeal cancer. NTP listed carcinogen. The use of products that contain or liberate formaldehyde is regulated under the OSHA Formaldehyde Standard (see 29 CFR 1910. 1048) . Studies conducted on laboratory animals indicate that exposures to parachlorobenzotriflouride via inhalation and ingestion may result in liver and kidney damage. In recent studies, fumed and precipitated synthetic amorphous silicas were fibrogenic to the lungs of monkeys, with the fumed form being the most active type. Overexposure to crystalline silica results in silicosis, a lung disease characterized by coughing, difficult breathing, wheezing, scarring of the lungs, and repeated, non-specific chest illnesses. The International Agency for Research on Cancer (IARC) has