COMPLIANCE INFO_1987-1998 - Laserfiche WebLink

Home Browse Search

H0140 ' aecaaaical r®action to s. , broken and -z of fibers. EYE: SLIGHTLY TO 140DERATELY IRRITATING. Abrasive action may cause damage to the outer surface of the eye, INHALATIbN: May cause respiratory tract irritation. Pre-existing medical conditions may be aggravated by exposure; specifically, bronchial hyper -reactivity and chronic bronchial or lung disease. SPECIAL TOXIC EFFECTS: Currently, there are no known chronic health effects in humans from long -ter= exposure tc ceramic fibers. In animal studies, refractory ceramic fibers injected into the peritoneal (abdominal) cavity have caused acute abdominal hemorrhage in hamsters but not in rats. Such injections into the abdominal or pleural cavities have also produced tumors in life -time rat and hamster studies. In fact, similar results have been observed with numerous other fibrous and non-fibrous materials. In such experiments, this• abnormally sensitive Injection technique is a non -physiological method of exposure, bypassing both normal pu2=onary protective and clearance mechanisms. Recently published inhalation studies have provided contradictory results. One study, which used rats as the experimental animal, reported lung damage consisting of alveolar proteinosis and interstitial fibrosis, whereas, other studies using rats and hamstars, showed no similar effects. Similarly, the pulmonary tumor -causing potential of refractory ceramic fibers in animals Is unclear. Two inhalation studies suggest a low -order potential in inducing pulmonary tumors in animals, while other inhalation and intratracheal injection studies conclude that ceramic fibers are not tumorigenic in animals. The International Agancy of Research on Cancer (IARC) has recently reviewed the animal, hi—an and other relevant experimental data on mea made mineral fibers in order to critically evaluate and classify the cancer causing potential of these materials. Based on its review, Z:.RC classified fibrous glass wool, mineral wool (both rock wool and slag wool) and ceramic fiber as group 2B carcinogens. By definition, a group 2B agent is possibly carcinogenic to hu-ans. For refractory ceramic fibers, IARC's 2B classification was based on sufficient evidence of carcinogenicity in experimental ani.als in the absence of human epidemiologic data. Further animal and hua-.an health studies; are planned. Pendi-ng the results of these studies, strict adherence to recommended safe work practices dasc=ibed elsewhere in this data sheet is advised. INGESTION: Do not induce w=aiting. Get medical attention it irritation persists, SKIN CONTACT: Rash area of contact thoroughly with soap and water. Do not rub or scratch exposed skin. t7sing a skin cream or lotion after washing may be helpful. Get medical attention if irritation persists. EYE CONTACT: Flush -3 diately with large amounts of water for at least 15 minutes, Eyelids should be held away from the eyeball to ensure thorough rinsing. Do not rub eyes. Get medical attention if irritation persists. ND - No Data NA - Not APPIioable 251 /Page 2 of 6 -15-