COMPLIANCE INFO_1987-1998 - Laserfiche WebLink

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mechanical r®action to A0, broken ends of fibers. M0I40 ' EYE: SLIGHTLY TO MODERATELY IRRITATING. Abrasive action may cause damage to the outer surface of the eye. INHALATION: May cause respiratory tract irritation. Pse -existing medical conditions may be aggravated by exposure; specifically, bronchial hypes -reactivity and chronic bronchial or lung disease. SPECIAL TOXIC EFFECTS: Currently, there are no known chronic health effects in humans from,long-terra exposure to ceramic fibers. In animal studies, refractory ceramic fibers injected into the peritoneal (abdominal) cavity have caused acute abdominal hemorrhage in hamsters but not in rats. Such injections into the abdominal or pleural cavities have also produced tumors in life -time rat and hamster studies. In fact, similar results have been obse rv-ed with numerous other fibrous and non-fibrous materials. In such experiments, this- abnormally sensitive Injection technique is a non -physiological method of exposure, bypassing both normal pu2.monary protective and clearance mechanisms. Recently published inhalation studies have provided contradictory results. one study, which used rats as the experimental animal, reported lung damage consisting of alveolar proteinosis and interstitial fibrosis, whereas, other studies using rats and hamsters, showed no similar effects. Similarly, the pulmonary tumor -causing potential of refractory ceramic fibers in aniaals is unclear. Two inhalation studies suggest a low -order potential in inducing pulmonary tumors in animals, while other inhalation and intratracheal injection studies conclude that ceramic fibers are not tumorigenic in animals. The International Agency of Research on Cancer (IARC) has recently reviewed the animal, h=an and other relevant experimental data on man made mineral fibers in order to critically evaluate and classify the cancer causing potential of these materials. Based on its review, IARC classified fibrous glass wool, mineral wool (both rock wool and slag wool) and ceramic fiber as group 2B carcinogens. By definition, a group 2B agent is possibly carcinogenic to humans. For refractory ceramic fibera, IARC's 2B classification was based on sufficient evidence of carcinogenicity in experimental anirals in the absence of husan epidemiologic data. Further animal and hu=an health studies are planned. Pending the results of these studies, strict adherence to reco=aended safe work practices described elsewhere in this data sheet is advised. �:J: :t � v � '\ wa•'-,Xa,,,�"fysa'.">? ] t �i <a w,. <� t iu- (.,� +Cc <x�r � isdarsfao/ h�: Y'<rw-.cV.Ka.a. i .*ri �v�L � .• ��ar �� .iv L. '�'' f i �, �< .+�, � < < Y. w �, �,t r<, 3 r � ti � iy f,,- f�a.��<.,yw,•*�) "'"."�Y"< S`;�?\.. .<^.'�': ... .-.. ...;?:»i. .>'..-�«:� i�%:.•:.. -•-.: -- <..?.. ,...> ..:.. �. .•.�%.^. Y,>XJ. . t.Y .r^'F vr+i.Ya` .>-..')�" �""1'b��1=2� s <,..`Y > INGESTION: Do not induce vomiting. Get medical attention if irritation persists. SKIN CONTACT: Wash area of contact thoroughly with soap and water. Do not rub or scratch exposed akin. Using a skin cream or lotion after washing may be helpful. Get medical attention if irritation persists. EYE CONTACT: Flush•isn ed.iately with large amounts of water for at least 15 minutes. Eyelids should be held away from the eyeball to ensure thorough rinsing. Do not rub eyes. Get medical attention is irritation persists. ND - No Data ` 251 /Page 2 of 6 NA - Not APPlicable -15-