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No 318 Xylene(Mixed Isomers) 9/92
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<br /> 6. Health Hazard Data continued
<br /> was reported in association with workplaceexposure to xylene perhaps due to effects on liver metabolism Xylene crosses the human
<br /> ut does not appear to be terato entc under conditions tested to date Medical Conditions Aggravated by Long-'Perm Exposure CNS
<br /> uatory.eye,stun,gastrointestinal(G1).liver and kidney disorders Target Organs:CNS,eyes,GI tract,liver,kidneys,and skin Primary
<br /> ry Routes:Inhalation,skin absorption(slight),eye contact,ingestion Acute Effects:Inhalation of high xylene concentrations may cause
<br /> izziness,nausea,vomiting,and abdominal pain,eye,nose,and throat natation,respiratory tract irritation leading to pulmonary edema(fluid in
<br /> lung),drowsiness,and unconsciousness Direct eye contact can result in conjunctivitis and corneal burns Ingestion may cause a burning sensation
<br /> in the oropharynx and stomach and transient CNS depression Chronic Effects•Repeated or prolonged skit contact may cause drying and defat-
<br /> ung of the skin leading to dermatius Repeated eye exposure to lugh vapor concentrations may cause reversible eye damage,peripheral and central
<br /> neuropathy,and liver damage,Other symptoms of chronic exposure include headache.fatigue,irritability.chronic bronchitis,and GI disturbances
<br /> such as nausea,loss of appetite,and gas
<br /> FIRST AID Emergency personnel should protect against exposure Eyes.Do not allow victim to rub or keep eyes ughtly shut.Gently lift eyelids
<br /> and flush immediately and continuously with flooding amounts of water until transported to an emergency medical facility Consult a physician
<br /> immediately Skin Quickly remove contaminated clothing Rinse with flooding amounts of water for at least 15 trim Wash exposed area with soap
<br /> and water For reddened or blistered skin,consult a physician Carefully dispose of contaminated clothing as it may pose a fire hazard Inhalation:
<br /> Remove exposed person to fresh air and support breathing as needed Monitor exposed person for respiratory distress Ingestion:Never give
<br /> anything by mouth to an unconscious or convulsing person Contact a poison control center and unless otherwise advised,do nog induce vomiting if
<br /> spontaneous vomiting should occur,keep exposed person's head below the hips to prevent aspiration(breathing liquid xylene into the lungs).
<br /> Aspiration of a few millimeters of xylene can carie chemical pneumonstis,pulmonary edema,and hemorrhage Note to Physicians:Hippunc acid
<br /> or the ether glucuronide of Ortho-toluic acid may be useful in diagnosis of meta-,para- and Ortho-xylene exposure,respectively Consider gastric
<br /> lavage if a large quantity of xylene was ingested Proceed gastric lavage with protection of the airway from aspiration,consider endotracheal
<br /> intubation with inflated cuff
<br /> Section 7. Spill,Leak,and Disposal Procedures
<br /> Spill/Leak Noufy safety personnel,evacuate all unnecessary personnel.remove all heat and ignition sources.and ventilate spill area Cleanup
<br /> personnel should protect agatmt vapor inhalation and skin or eye contact.If feasible and without undue risk,stop leak.Use appropriate foam to
<br /> blanket release and suppress vapors Water spray may reduce vapor,but does not prevent ignition to closed spaces For small spills,absorb on paper
<br /> and evaporate in appropriate exhaust hood or absorb with sand or some non-combusuble absorbent and place in contains for latex disposal For
<br /> large spills dike far ahead of liquid to contain Do not allow xylene to enter a confined space such as sewers or drains On land,dike to contain or
<br /> divert to impermeable holding area Apply water spray to control flammable vapor and remove material with pumps or vacuum equipment.On
<br /> water,contain material with natural barriers,booms,or weirs,apply universal gelling agent,and use suction loses to remove spilled material
<br /> Report any release in excess of FOOD lb Follow applicable OSHA regulations(29 CFR 1910 120) Environmental Transport-Little bioconcen-
<br /> tration is expected Biological oxygen demand 5(after 5 days at 20'C) 0 64(no stated isomer) Ecotoxicity values:LD50,Goldfish,13 rn"4 hr,
<br /> conditions of bioassay not specified,no specific isomer Environmental Degradation:In the atmosphere,xylenes degrade by reacting with
<br /> phowchemically produced hydroxyl radicals with a half-life ranging from 1-17 hr in the summer to 10-18 hr tri winter or a typical loss of 67-86%
<br /> per day Xylenes are resistant to hydrolysis Soil Absorption/Mobliity:Xylenes have low to moderate adsorption to soil and when spilled on land,
<br /> volatilize and leach into groundwater Disposal.As a hydrocarbon,xylene is a good candidate for controlled incuierauon.Contact your supplier
<br /> licensed contractor for detailed recommendations Follow applicable Federal,state,and local regulations
<br /> A Designations OSHA Designations
<br /> SARA Extremely Hazardous Substance(40 CFR 355) Not listed Lasted as an Air Contaminant(29 CFR 19101000,Table Z-1-A)
<br /> Listed as a SARA Toxic Chemical(40 CFR 372 65)
<br /> Listed as a RCRA Hazardous Waste(40 CFR 261 33) No U239.F003(spent solvent)
<br /> Listed as a CERCLA Hazardous Substance)(40 CFR 302 4) Final Reportable Quantity(RQ),1000 lb(454 kg)[*per Clean Water Act,
<br /> Sec 311(b)(4),per RCRA,Sec 30011
<br /> Section 8. Special Protection Data
<br /> Goggles Wear protective eyeglasses or chemical safety goggles,per OSHA eye-and face-protection regulations(29 CFR 1910133) Bemuse
<br /> contact lens use in industry is controversial.establish your own policy Respirator:Seek professional advice prior to respirator selection and use
<br /> Follow OSHA respirator regulations(29 CFR 1910 134)and.if necessary,wear a MSHA/NIOSH-approved respirator For concentrations>1000
<br /> ppm,use any chemical cartridge respirator with organic vapor cartridges,any powered,air-punfying respirator with organic vapor cartridges,any
<br /> supplied-air respirator,or any self-contained breathing apparatus For emergency or nonroutine operations(cleaning spills,reactor vessels,or
<br /> storage tanks),wear an SCI Warnixgr Air-purifying respirators do not protect workers to oxygen-deficient atmospheres If respuators are used,
<br /> Other Wear chemically protective gloves,boots,aprons,and gauntlets to prevent all skin contact.With breakthrough times>8 hr,consider
<br /> polyvinyl alcohol and fluorocarbon rubber(Vicon)as materials for PPI~.Ventilation:Provide general and local exhaust ventilation systems to
<br /> maintain airborne concentrations below the OSHA PELs(Sec.2) Local exhaust ventilation is preferred because it prevents contaminsint dispersion
<br /> into the work area by controlling it at its source(103)Safety Stations:Make available in the work area emergency eyewash stations.safety/quick-
<br /> drench showers,and washing facilities Contaminated Equipment:Separate contaminated work clothes from street clothes Launder cona mt-
<br /> hated work clothing before wearing Remove this material from your shoes and clean PPE Comments:Never eat,drink,or sntioke in work areas
<br /> Practice good personal hygiene after using this material,especially before eating,dr liking,smoking,using the toilet,or applying cosmetics
<br /> Section 9. Special Precautions and Comments
<br /> Storage Requirements:Store in clearly labelled,ughtly closed,containers in a cool,well-ventilated place,away from strong oxidizing materials
<br /> and heat and ignition sources During traraferring operations.electrically ground and bond metal containers Engineering Controls:To reduce
<br /> potential health hazards,use sufficient dilution or local exhaust ventilation to control airborne contaminants and to maintain concentrations at the
<br /> lowest practical level Use hermetically sealed equipment.transfer xylene in enclosed systems,avoid processes associated with open evaporating ;
<br /> surfaces,and provide sources of gas release with enclosures and local exhaust ventilation Use Class L Group D electrical equipment Administra-
<br /> tive Controls-Establish ani and biological monitoring programs and evaluate regularly Consider preplacement and periodic medtcal examinations
<br /> including a complete blood count,a routine unnalysts,and liver function tests.Consider hematologic studies of there is any significant contamination
<br /> of the solvent with benzene.If feasible,consider the replacement of xylene by less toxic solvents such as petrol(motor fuel)or white spirit Before
<br /> carrying out maintenance and repair work,steam and flush all equipment to remove any xylene residues.
<br /> Transportation Dats(49 CFR 172.101)
<br /> Shipping Name.Xylenes Packaging Authorizations ,I E Quantity Litnitatlons i Vessel Stowage Requirements
<br /> IDOT
<br /> Hazard Class.3 a) Exceptions 173 150 ! a)Passenger,Aircraft,or Railcar 5L I a)Vessel Stowage.B
<br /> o UN 1307 b)Nonbulk Packaging 173.202 b)Cargo Aircraft Only 60L I 1 b)Other�- � ,' III
<br /> ' 1 asking Group.11 c)Bulk Packaging 173.242 I i I I
<br /> Label.Flammable L t uid
<br /> ial Provisions(172.102) Tl
<br /> SGollereori'Referencex 26,'73;89,100,IDI,103;124,126,127,1132,133,136,139,140,148,149,153,159,163,164,167,171,174, 176,180ared by MJ Wunh,BS,Industrial1Hygtesne Review,PA Roy,'MMPH,CIH Medical Review'WSilverman,MD
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