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Carbon and Alloy Steels <br />pigmentation of the affected area. Ingestion overexposures to iron may affect the gastrointestinal, nervous, <br />and hematopoietic system and the liver. Iron and steel founding, but not iron or iron oxide, has been listed <br />as carcinogenic (Group 1) by IARC. <br />When this product is welded, fumes are generated. Welding fumes may be different in composition from <br />the original welding product, with the chief component being ordinary oxides of the metal being welded. <br />Chronic health effects (including cancer) have been associated with the fumes and dusts of individual <br />component metals (see above), and welding fumes as a general category have been listed by IARC as a <br />carcinogen (Group 2B). There is also limited evidence that welding fumes may cause adverse reproductive <br />and fetal effects. Evidence is stronger where welding materials contain known reproductive toxins, e.g., <br />lead, which may be present in the coating material of this product. <br />Breathing fumes or dusts of this product may result in metal fume fever, which is an illness produced by <br />inhaling metal oxides. These oxides are produced by heating various metals including cadmium, zinc, <br />magnesium, copper, antimony, nickel, cobalt, manganese, tin, lead, beryllium, silver, chromium, aluminum, <br />selenium, iron, and arsenic. The most common agents involved are zinc and copper. <br />This product may contain small amounts of manganese. Prolonged exposure to manganese dusts or <br />fumes is associated with "manganism", a Parkinson -like syndrome characterized by a variety of <br />neurological symptoms including muscle spasms, gait disturbances, tremors, and psychoses. <br />This product may contain small amounts of cadmium. Primary target organs for cadmium overexposure <br />are the lung and the kidney. Because of its cumulative nature, chronic cadmium poisoning can cause <br />serious disease which takes many years to develop and may continue to progress despite cessation of <br />exposure. Progression of the disease may not reflect current exposure conditions. It is also capable of <br />causing a painful osteomalacia called "Itai-Itai" in postmenopausal women, and has caused developmental <br />effects and/or reproductive effects in male and female animals. Cadmium is a listed carcinogen by NTP, <br />OSHA, and IARC (Group 1). <br />This product may contain small amounts of chromium. Prolonged and repeated overexposure to chromium <br />dusts or fumes may cause skin ulcers, nasal irritation and ulceration, kidney damage and cancer of the <br />respiratory system. Chromium is skin sensitizer. Cancer is generally attributed to the hexavalent (+6) form <br />of chromium which is listed as a carcinogen by NTP and IARC (Group 1). <br />This product may contain small amounts of nickel. Prolonged and repeated contact with nickel may cause <br />sensitization dermatitis. Inhalation of nickel compounds has caused lung damage as well as sinus, nasal <br />and lung cancer in laboratory animals. Nickel is a listed carcinogen by NTP and IARC (Group 1). <br />This product may contain small amounts of vanadium. Adverse effects from dermal, inhalation or <br />parenteral exposure to various vanadium compounds have been reported. The major target for vanadium <br />pentoxide toxicity is the respiratory tract. Fumes or dust can cause severe eye and respiratory irritation, <br />and systemic effects. Chronic bronchitis, green tongue, conjunctivitis, pharyngitis, rhinitis, rales, chronic <br />productive cough, and tightness of the chest have been reported following overexposure. Allergic <br />reactions resulting from skin and inhalation exposures have also been reported. A statistical association <br />between vanadium air levels and lung cancer has been suggested, but vanadium currently is not regarded <br />as a human carcinogen. <br />This product may contain small amounts of lead. Lead can accumulate in the body. Consequently, <br />exposure to fumes or dust may produce signs of polyneuritis, diminished vision and peripheral neuropathy, <br />such as tingling and loss of feeling in fingers, arms and legs. Lead is a known reproductive and <br />developmental toxin. It is also associated with central nervous system disorders, anemia, kidney <br />dysfunction and neurobehavioral abnormalities. The brain is a major target organ for lead exposure. <br />Elemental lead is listed as an IARC 2B carcinogen. <br />The product may contain small amounts of copper. Copper dust and fumes can irritate the eyes, nose and <br />throat causing coughing, wheezing, nosebleeds, ulcers and metal fume fever. Other effects from repeated <br />Page 6 of 8 Revision Date: 7/25/2013 <br />