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ARkEMA SAFETY DATA SHEET <br /> CERTINCOATO TC - 100 Coating Material <br /> Repeated inhalation administration to rat / affected organ (s) : lung / signs: respiratory irritation , <br /> inflammation , lung edema , changes in blood cell counts / Local irritation of the respiratory system <br /> (extent of injury depends on severity of exposure) <br /> Genotoxicity <br /> Assessment in Vitro : <br /> Both positive and negative responses for genetic changes were observed in laboratory tests using : <br /> bacteria , animal cells <br /> Genotoxicity <br /> Assessment in Vivo : <br /> No genetic changes were observed in laboratory tests using : mice <br /> Developmental toxicity <br /> Exposure during pregnancy. oral (rat) / No birth defects were observed . <br /> Reproductive effects <br /> Exposure prior to mating . dietary (rat) / No toxicity to reproduction <br /> Data for Stannane, dibutyldichloro- ( 683-18-1 ) <br /> Acute toxicity <br /> Oral : <br /> Toxic if swallowed . (rat) LD50 = 219 mg/kg . <br /> Dermal : <br /> Harmful in contact with skin . (estimate based on composition) <br /> Inhalation : <br /> Fatal if inhaled . (rat) 4 h LC50 = 0. 06 mg/I . (dust/mist) <br /> Fatal if inhaled . (rat) 1 h LC50 = 0. 1 mg/I . (dust/mist) <br /> Specific target organ toxicity = single exposure : <br /> Causes damage to organs. (thymus) <br /> Skin Irritation : <br /> Causes severe skin burns . (rabbit) (5 min) <br /> Eye Irritation : <br /> Causes serious eye damage. (rabbit) <br /> Skin Sensitization : <br /> May cause allergic skin reaction . Buehler method . (guinea pig) Skin allergy was observed . <br /> Repeated dose toxicity <br /> Repeated dietary administration to rat / affected organ (s) : thymus / signs : changes in organ structure or <br /> function <br /> Specific target organ toxicity - repeated exposure: <br /> Product code: 13I1300 Version 3 .2 Issued on : 07/ 18/2018 Page : 10 / 15 <br /> Page 10/ 16 <br /> Quick-FDS [ 19050-00814-08435-011984] - 2020-02-26 - 00: 13 :35 <br />