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WACKER <br /> Safety Data Sheet <br /> Material : 60004600 HDK® N20 <br /> HYDROPHILIC PYROGENIC SILICA <br /> Version : 2. 1 (US) Date of print: 06/25/2015 Date of last alteration : 06/24/2015 <br /> by inhalation LC50: > 0 . 139 mg/I; 4 h rat literature <br /> (dust) t the technically highest possible concentration no <br /> mortality in animal test. <br /> 11 .1 . 2 Skin corrosion/irritation <br /> Assessment : <br /> Based on the available data a clinically relevant skin irritation hazard is not expected . <br /> Product details : <br /> Result/Effect eciesfTest system Isource <br /> not irritating rabbit literature <br /> 11 .1 . 3 Serious eye damage / eye irritation <br /> Assessment : <br /> Based on the available data a clinically relevant eye irritation hazard is not expected . <br /> Product details: <br /> Result/Effect ecies/Test system ISource <br /> not irritating rabbit Iliterature <br /> 11 . 1 .4 Respiratory or skin sensitization <br /> Assessment: <br /> By handling the product for many years no damage to health was observed . <br /> 11 . 1 .5 Germ cell mutagenicity <br /> Assessment: <br /> According to our present state of knowledge not mutagenic. <br /> 11 . 1 .6 Carcinogenicity <br /> Assessment: <br /> Animal tests have not revealed any carcinogenic effects . <br /> 11 . 1 .7 Reproductive toxicity <br /> Assessment: <br /> In animal experiments there have not been any indications of reproduction toxicity. <br /> 11 . 1 .8 Specific target organ toxicity (single exposure) <br /> Assessment: <br /> For this endpoint no toxicological test data is available for the whole product. <br /> 11 .1 .9 Specific target organ toxicity ( repeated exposure) <br /> Assessment: <br /> Changes in the lungs (inflammatory processes) observed in animal experiments after chronic inhalative exposure were reversible ; <br /> no indication of silicosis . <br /> 11 . 1 . 10 Aspiration hazard <br /> Assessment: <br /> For this endpoint no toxicological test data is available for the whole product. <br /> 11 . 1 . 11 Further toxicological information <br /> No component of this product present at levels greater than or equal to 0A % is identified as a known or anticipated carcinogen by <br /> NTP . No component of this product present at levels greater than or equal to 0. 1 % is identified as probable , possible or confirmed <br /> human carcinogen by IARC . No component of this product present at levels greater than or equal to 0 . 1 % is identified as a <br /> carcinogen or potential carcinogen by OSHA. <br /> Page : 5/8 <br />