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STATE of CALIFORNIA <br /> DEPARTMENT <br /> TOXIC SUBSTANCES CONTROL PROGRAM <br /> TOXICOIAGY AND RISK ASSESSMENT UNIT <br /> SCIENTIFIC GUIDANCE 89-3 <br /> AUGUST 9 , <br /> Page 4 of 8 <br /> air <br /> These AALs represent the concentaot one of thesen median over ea <br /> which, if humans were expose <br /> d twould be expected to cause no more than ^ne extra <br /> cancer in one million exposed individuals. The actua. . riskk o <br /> lifetime, <br /> In applying these <br /> cancer could be lower an ort nt to uld erecbognize .that exposures from <br /> and other AALs it is imp and the toxicity <br /> different media are consideredheo becumulative, <br /> adverse effect, e.g• <br /> of substances producing <br /> carcinogens, or by the same mode of action are considered <br /> For example, to estimate the total cancer is <br /> cumulative. ks posed <br /> to exposure to PCP at a wood treatment water, soil) need to be <br /> by exposures from all media (air, <br /> Furthermore, in <br /> determined and exposures to k complex mixtures,be <br /> shouthen the <br /> again taking the <br /> dealing withsite, to estimate total cancer risk <br /> example of a wood preserving the risk posed by <br /> in a potentially exposed population,ium+6 polycyclic aromatic <br /> carcinogens (PCP, arsenic, chrom , <br /> al <br /> carbons, etc. ) should be det r min risks summedcto obtain the <br /> hydrocarbons, <br /> chemical for each medium, and then t <br /> total risk. of <br /> Toxicology P is the first <br /> and Risk Assessment Unit <br /> determine Ca health-based <br /> The T tate or federal , effects of <br /> regulatory body, son the carcinogenic <br /> standard based p standards , i. e. AALs , are <br /> exposure phenol. <br /> The DHS-TSC( _ than current <br /> pentachloro- P, more stringent) The <br /> roughly 500 times lower o*her regulatory agencies. <br /> been used tlatory action in <br /> health-baso support a regu <br /> ed criteria used by <br /> AALs have already <br /> California. <br /> This summary was prepared by: <br /> John H. Brantner, Ph.D. , DABT <br /> John P. Christopher, Ph.D. , DABT <br /> Richard A. Becker, Ph.D. <br /> Jeffrey J. Wong, Ph. D. <br /> Toxicology and Risk Assessment Unit <br /> Technical Services <br /> Toxic Substances control Program <br /> Health Services <br /> State of California Dep <br /> ar"C'ment of 714/744 P Street <br /> p. O. Box 942732 <br /> Sacramento, CA 94234-7320 <br /> (916) 445-7410. <br />