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STATE OF CALIFORNIA <br /> DEPARTMENT OF HEALTH SERVICES <br /> TOXIC SUBSTANCES CONTROL PROGRAM <br /> TOXICOLOGY AND RISK ASSESSMENT UNIT <br /> SCIENTIFIC GUIDANCE MEMO 89-3 <br /> AUGUST 9, 1989 <br /> Page 8 of 8 <br /> Table 2. The incidence of ttimors in mice exposed <br /> to EC-7 grade <br /> pentachlorophenol in the diet for 104 weeks. These data <br /> were used in low dose extrapolation. <br /> EC-7 grade pentachlorophenol <br /> First* <br /> TI-mor <br /> Site Sex wks Dose Level (mom <br /> M 0 18 37 118 <br /> F 0 17 34 114 <br /> Liver I�mm ** <br /> or Incidence <br /> I CIS*** <br /> Hepatocellular M 77 6/28 19/41 21/37 34/44 6.28E-5 <br /> Ad. or Case. F 96 1/33 4/34 6/44 31/43 15.2E-5 <br /> (combined) <br /> Adrenal Medulla F 80 0/34 2/39 61/38 45/45 16.8E-5 <br /> 2/48 38/45 53.8E-5 <br /> Pheo. or Malig. <br /> Pheo. (combined) <br /> Circulatory System F 88 0/34 1/39 3/48 9/45 34.4E-5 <br /> Hemangioma or <br /> Henangiosarcoma <br /> (combined) <br /> * Tumors appeared first in high dose group at all sites. <br /> ** 7---or incidence adjusted by s:bt_•acting deaths before <br /> appearance of first tumor frcm the denominator since these <br /> ari'7als were not considered to be at risk. <br /> *** LcL = 95% lower confidence limit on dose from linearized <br /> rr-.lti stage model. <br />