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Section 11._ ToxacoloInfoxmaietrioGinue %% Causes damage to lungs through prolonged or repeated inhalation STOST following Repeating Exposure 1i <.. WARNING exposure. Causes damage to the central nervous s stem Notes: a. No LC50 or LD50 has been established for Stainless Steel (semi -finished steel products). The following data has been determined for the components: • Iron: LD50= 1060 mg/kg (Oral/ Rat) • Manganese: Mn single oral exposures, LD50 ranged from 275 to 804 mg/kg body weight per day for manganese chloride in different rat strains • Chromium (as Cr +VI): LD50 = 80 mg/kg (Oral/Rat) • Silicon: LD50 = 3160 mg/kg (Oral/Rat); and as Silicon Dioxide: LD50 > 15,000 mg/kg (Oral/Rat) ; LD50 > 5000 mg/kg (Dermal/Rat); LC50 > 0.69 mg/I/4hr (Inhalation/Rat) • Nickel: LD50 > 9000 mg/kg (Oral/Rat); LC50 > 10.2 mg/I (Inhalation/Rat) • Boron: LD = 650 mg/kg (Oral/Rat) b. No Skin (Dermal) Irritation data available for Stainless Steel (semi -Finished steel products) as a mixture. The following Skin (Dermal) Irritation information was found for the components: • Iron: Causes skin irritation • Chromium (as Cr +VI): Corrosive. Human skin sensitizer • Nickel: Slight irritation only in rabbits • Molybdenum: Irritating • Tungsten: Shin contact may cause irritation due to abrasive action of the dust c. No Eye Irritation data available for Stainless Steel (semi -finished steel products) as a mixture. The following Eye Irritation information was found for the components: • Iron, Molybdenum: Causes eye irritation • Silicon: Slight eye irritation in rabbit protocol • Chromium (as Cr +VI): Corrosive • Nickel: Slight eye irritation from particulate abrasion only. • Tungsten: Eye contact may cause irritation due to abrasive action of the dust d. No Skin (Dermal) Sensitization data available for Stainless Steel (semi -finished steel products) a mixture. The following Skin (Dermal) Sensitization information was found for the components: • Nickel: Human skin sensitizer • Copper, Chromium (as Cr +VI): May cause allergic skin reaction • Copper: It is reported that copper may induce allergic contact dermatitis in susceptible individuals e. No Respiratory Sensitization data available for Stainless Steel (semi -finished steel products) a mixture. The following Respiratory Sensitization information was found for the components: • Chromium (as Cr+VI): Occupational asthma reported in workers f No Germ Cell Mutagenicity data available for Stainless Steel (semi -finished steel products) as a mixture. The following Mutagenicity and Genotoxicity information was found for the components: • Iron: Some positive and negative findings in vitro • Chromium (as Cr +VI): Positive in in vitro and in vivo assays including cell transformation in vitro and dominant lethal in vivo • Nickel: Positive results in vitro and in vivo but insufficient data for classification • Aluminum: Not mutagenic in vitro; but has marginal effects in vivo g. Carcinogenicity: IARC, NTP, and OSHA do not list Stainless Steel (semi -finished steel products) as carcinogens. The following Carcinogenicity information was found for the components: • Welding Fumes, IARC Group 2B carcinogen, a mixture that is possibly carcinogenic to humans. • Nickel and certain nickel compounds - IARC Group 2B carcinogens that are possibly carcinogenic to humans. Insoluble nickel compounds - ACGIH confirmed human carcinogen. Nickel - EURAR Insufficient evidence to conclude carcinogenic potential in animals or humans; suspect carcinogen classification Category 2 Suspected of causing cancer. Nickel Oxide - HSDB listed as Category 1a, may cause cancer. Human data in which exposure to nickel refinery dust caused lung and nasal tumors. • Chromium metal and trivalent chromium compounds - IARC Group 3 carcinogens, not classifiable as to their human carcinogenicity. Hexavalent chromium compounds - IARC as Group 1 carcinogens, carcinogenic to humans. Chromium metal - ACGIH not classifiable as a human carcinogen. NTP Fourth Annual report on Carcinogens cites "certain Chromium compounds" as human carcinogens. h. No Toxic Reproduction data available for Stainless Steel (semi -finished steel products) as a mixture. The following Toxic Reproduction information was found for the components: • Hexavalent Chromium: Developmental toxicity in the mouse. • Nickel: Oral administration to experinnental animals caused fetotoxicity. • Aluminum: May cause delay in development of neurobehavioral indices. I. No Specific Target Organ Systemic Toxicity (STOST) following a Single Exposure data available for Stainless Steel (semi -finished steel products) as a mixture. The following STOST following a Single Exposure data was found for the components: • iron, Molybdenum: May cause respiratory irritation. Rev. Date May - 2015 6 PSM -SDS -SS