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• The primary component of this product is iron. Long-term exposure to iron dusts or fumes can result in a condition called siderosis which is <br />considered to be a benign pneumoconiosis. Symptoms may include chronic bronchitis, emphysema, and shortness of breath upon exertion. <br />Penetration of iron particles in the skin or eye may cause an exogenous or ocular siderosis which may be characterized by a red -brown <br />pigmentation of the affected area. Ingestion overexposures to iron may affect the gastrointestinal, nervous, and hematopoietic system and <br />the liver. Iron and steel founding, but not iron or iron oxide, has been listed as carcinogenic (Group 1) by IARC. <br />• When this product is welded, fumes are generated. Welding fumes may be different in composition from the original welding product, with <br />the chief component being ordinary oxides of the metal being welded. Chronic health effects (including cancer) have been associated with <br />the fumes and dusts of individual component metals (see above), and welding fumes as a general category have been listed by IARC as a <br />carcinogen (Group 2B). There is also limited evidence that welding fumes may cause adverse reproductive and fetal effects. Evidence is <br />stronger where welding materials contain known reproductive toxins, e.g., lead which may be present in the coating material of this product. <br />• Breathing fumes or dusts of this product may result in metal fume fever, which is an illness produced by inhaling metal oxides. These oxides <br />are produced by heating various metals including cadmium, zinc, magnesium, copper, antimony, nickel, cobalt, manganese, tin, lead, <br />beryllium, silver, chromium, aluminum, selenium, iron, and arsenic. The most common agents involved are zinc and copper. <br />• This product may contain small amounts of manganese. Prolonged exposure to manganese dusts or fumes is associated with "manganism", <br />Parkinson -like syndrome characterized by a variety of neurological symptoms including muscle spasms, gait disturbances, tremors, and <br />psychoses. <br />• This product may contain small amounts of cadmium. Primary target organs for cadmium overexposure are the lung and the kidney. Because <br />of its cumulative nature, chronic cadmium poisoning can cause serious disease which takes many years to develop and may continue to <br />progress despite cessation of exposure. Progression of the disease may not reflect current exposure conditions. It is also capable of causing a <br />painful osteomalacia called "Itai-Itai" in postmenopausal women, and has caused developmental effects and/or reproductive effects in male <br />and female animals. Cadmium is a listed carcinogen by NTP, OSHA, and IARC (Group 1). <br />• This product may contain small amounts of chromium. Prolonged and repeated overexposure to chromium dusts or fumes may cause skin <br />ulcers, nasal irritation and ulceration, kidney damage and cancer of the respiratory system. Chromium is skin sensitizer. Cancer is generally <br />attributed to the hexavalent (+6) form of chromium which is listed as a carcinogen by NTP and IARC (Group 1). <br />• This product may contain small amounts of nickel. Prolonged and repeated contact with nickel may cause sensitization dermatitis. Inhalation <br />of nickel compounds has caused lung damage as well as sinus, nasal and lung cancer in laboratory animals. Nickel is a listed carcinogen by <br />NTP and IARC (Group 1). <br />• This product may contain small amounts of vanadium. Adverse effects from dermal, inhalation or parenteral exposure to various vanadium <br />compounds have been reported. The major target for vanadium pentoxide toxicity is the respiratory tract. Fumes or dust can cause severe <br />eye and respiratory irritation, and systemic effects. Chronic bronchitis, green tongue, conjunctivitis, pharyngitis, rhinitis, rales, chronic <br />productive cough, and tightness of the chest have been reported following overexposure. Allergic reactions resulting from skin and <br />inhalation exposures have also been reported. A statistical association between vanadium air levels and lung cancer has been suggested, but <br />vanadium currently isnot regarded as a human carcinogen. <br />• This product may contain small amounts of lead. lead can accumulate in the body. Consequently, exposure to fumes or dust may produce <br />signs of polyneuritis, diminished vision and peripheral neuropathy, such as tingling and loss of feeling in fingers, arms and legs. Lead is a <br />known reproductive and developmental toxin. <br />• It is also associated with central nervous system disorders, anemia, kidney dysfunction, and neurobehavioral abnormalities. The brain is a <br />major target organ for lead exposure. Elemental lead is listed as an IARC 26 carcinogen. <br />• The product may contain small amounts of copper. Copper dust and fumes can irritate the eyes, nose and throat causing coughing, <br />wheezing, nosebleeds, ulcers and metal fume fever. Other effects from repeated inhalation of copper fumes include a metallic or sweet <br />taste, and discoloration of skin, teeth or hair. Copper also may cause an allergic skin reaction. Overexposure to copper can affect the liver. <br />Paves a of 7 Rev. 515 <br />